INT275865

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.33
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PES1) nucleoplasm (PES1) nucleolus (PES1)
nucleus (PES1) intracellular (PES1)
Anatomy Link Frequency
fat 2
PES1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 18 99.34 Very High Very High Very High
Chronic pancreatitis 110 93.52 High High
Bioavailability 2 83.84 Quite High
Potency 2 75.76 Quite High
Cholecystokinin 14 60.52 Quite High
Pain 40 43.84 Quite Low
alcohol 8 22.00 Low Low
Dysuria 2 11.52 Low Low
Bile 18 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 18 99.34 Very High Very High Very High
Appetite Loss 18 97.40 Very High Very High Very High
Pancreatitis 110 93.52 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 84.32 Quite High
Congenital Anomalies 2 79.72 Quite High
Obesity 2 75.36 Quite High
Diabetic Nephropathy 2 67.08 Quite High
Diabetes Mellitus 14 65.80 Quite High
Ataxia 2 63.84 Quite High
Osteoporosis 2 47.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unfortunately, therapeutic failures (gastrointestinal symptoms and fat malabsorption) have been noted in patients with CF after pharmacists substituted a preferred brand of PES with generic pancrelipase, which rapidly resolved after initial therapy was reinstituted.105
Negative_regulation (preferred) of PES Binding (brand) of in fat associated with fibrosis
1) Confidence 0.19 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 0.19 Pain Relevance 0.13
Improvement in gallbladder contraction with PES has been demonstrated in some studies36,37 but not in others.7

Malnutrition

Negative_regulation (Improvement) of PES Binding (contraction) of associated with appetite loss
2) Confidence 0.19 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 1.05 Pain Relevance 0.50

General Comments

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