INT275868

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.79
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PES1) nucleoplasm (PES1) nucleolus (PES1)
nucleus (PES1) intracellular (PES1)
Anatomy Link Frequency
blood 3
bile 1
B12 1
PES1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 54 99.04 Very High Very High Very High
Chronic pancreatitis 330 95.84 Very High Very High Very High
fibrosis 54 84.72 Quite High
antagonist 12 79.52 Quite High
alcohol 24 67.32 Quite High
depression 2 66.88 Quite High
Pain 120 50.24 Quite High
anesthesia 2 5.68 Low Low
Cholecystokinin 42 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epstein-barr Virus 5 99.84 Very High Very High Very High
Diabetes Mellitus 42 99.00 Very High Very High Very High
Hypoglycemia 6 98.58 Very High Very High Very High
Pancreatitis 330 95.84 Very High Very High Very High
Steatorrhea 102 95.28 Very High Very High Very High
Disorder Of Lipid Metabolism 12 92.72 High High
Weight Loss 6 88.56 High High
Body Weight 20 86.92 High High
Cystic Fibrosis 54 84.72 Quite High
Intestinal Obstruction 6 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One randomized controlled trial with PES in patients with apancreatic diabetes revealed major difficulties with controlling blood sugars on changing from active enzyme replacement to placebo and vice versa, suggesting that enzyme adjustment should be carefully supervised in a hospital.16 In another randomized controlled trial of insulin- dependent diabetics with PEI, there were no significant differences in hemoglobin A1C, fasting glucose levels, or 2-hour postprandial glucose levels in patients receiving PES as compared to those not receiving PES.51 A reduction in mild and moderate hypoglycemia was observed in patients receiving PES and the authors concluded that PES therapy can be used safely in patients with diabetes mellitus and exocrine dysfunction.


Positive_regulation (used) of PES in blood associated with hypoglycemia and diabetes mellitus
1) Confidence 0.23 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 0.78 Pain Relevance 0.13
One randomized controlled trial with PES in patients with apancreatic diabetes revealed major difficulties with controlling blood sugars on changing from active enzyme replacement to placebo and vice versa, suggesting that enzyme adjustment should be carefully supervised in a hospital.16 In another randomized controlled trial of insulin- dependent diabetics with PEI, there were no significant differences in hemoglobin A1C, fasting glucose levels, or 2-hour postprandial glucose levels in patients receiving PES as compared to those not receiving PES.51 A reduction in mild and moderate hypoglycemia was observed in patients receiving PES and the authors concluded that PES therapy can be used safely in patients with diabetes mellitus and exocrine dysfunction.


Neg (not) Positive_regulation (receiving) of PES in blood associated with hypoglycemia and diabetes mellitus
2) Confidence 0.23 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 0.85 Pain Relevance 0.12
The resulting acidic intraduodenal milieu is responsible for the irreversible inactivation of pancreatic lipase,73,74 and the decreased functioning of bile salts.64 It has been demonstrated that patient response to conventional PES is enhanced if gastric acid secretion is suppressed.75
Positive_regulation (response) of PES in bile associated with bile
3) Confidence 0.23 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 0.15 Pain Relevance 0.17
These genes have produced large amounts of human lipase, and in the future, ectopic expression of human lipase in the pancreatobiliary system may become an available treatment modality.63

When to initiate PES

Positive_regulation (initiate) of PES
4) Confidence 0.23 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 0.68 Pain Relevance 0.30
Based on in vitro tests, Aloulou et al propose that the efficacy of enteric coated PES could be enhanced by adding unprotected enzymes.
Positive_regulation (enhanced) of PES
5) Confidence 0.23 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 0.42 Pain Relevance 0.20
PES, however, is not sufficient for correcting fat soluble vitamin (A, D, E and K) deficiencies or B12 deficiency, without simultaneous vitamin supplementation.38,44

Endocrine insufficiency

Neg (not) Positive_regulation (sufficient) of PES in B12
6) Confidence 0.21 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 1.24 Pain Relevance 0.41
Our calculations show that blood volume significantly increased relatively to baseline after hemodilution for all PEs.
Positive_regulation (increased) of PEs in blood
7) Confidence 0.12 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937285 Disease Relevance 0.67 Pain Relevance 0.06

General Comments

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