INT27587

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Context Info
Confidence 0.46
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 6.37
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (STAR) transport (STAR) mitochondrion (STAR)
small molecule metabolic process (STAR)
Anatomy Link Frequency
plasma 2
leucocytes 1
STAR (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 3 99.40 Very High Very High Very High
Pain 2 96.84 Very High Very High Very High
alcohol 16 89.72 High High
Infliximab 62 86.64 High High
rheumatoid arthritis 20 67.60 Quite High
methotrexate 14 54.36 Quite High
headache 3 32.60 Quite Low
Arthritis 2 18.48 Low Low
Action potential 5 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 115 100.00 Very High Very High Very High
Bacteremia 2 99.62 Very High Very High Very High
Infection 6 99.54 Very High Very High Very High
Microvascular Angina 1 99.40 Very High Very High Very High
Pruritus 1 98.84 Very High Very High Very High
Stress 46 98.34 Very High Very High Very High
Pain 1 96.84 Very High Very High Very High
Bacterial Pneumonia 1 96.80 Very High Very High Very High
Cv General 3 Under Development 2 96.68 Very High Very High Very High
Fever 1 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three out of 17 patients with Staphylococcus aureus bacteremia had significantly increased anti-STAR antibody levels (150, 75 and 75 micrograms/ml), and STAR neutralizing activities (2.2, 3.6 and 4.1 micrograms STAR neutralized per ml plasma, respectively).
Positive_regulation (increased) of STAR in plasma associated with bacteremia
1) Confidence 0.46 Published 1994 Journal Thromb. Haemost. Section Abstract Doc Link 8165631 Disease Relevance 0.29 Pain Relevance 0.10
Three out of 17 patients with Staphylococcus aureus bacteremia had significantly increased anti-STAR antibody levels (150, 75 and 75 micrograms/ml), and STAR neutralizing activities (2.2, 3.6 and 4.1 micrograms STAR neutralized per ml plasma, respectively).
Positive_regulation (increased) of anti-STAR in plasma associated with bacteremia
2) Confidence 0.40 Published 1994 Journal Thromb. Haemost. Section Abstract Doc Link 8165631 Disease Relevance 0.28 Pain Relevance 0.10
Our clinical investigation was aimed at assessing noninvasively the integrative coronary flow response to dipyridamole stress in 18 consecutive patients with microvascular angina, only moderately elevated LDL-cholesterol levels (168 +/- 33 mg/dl), and reduced vasodilator capacity despite normal (n = 9) or slightly abnormal (n = 9) coronary arteriograms (minimal disease with luminal irregularities and/or diameter reduction < or = 30%) before and after 6-month lipid-lowering therapy (simvastatin).
Positive_regulation (elevated) of LDL-cholesterol associated with stress, angina, disease and microvascular angina
3) Confidence 0.34 Published 1998 Journal Z Kardiol Section Abstract Doc Link 9827472 Disease Relevance 0.62 Pain Relevance 0.10
1) The Solid trace is the response to Dau-chirp stimuli jittered at a mean rate of 15 S/s (same sequence as used for timing the start-to-start of the pairs).
Positive_regulation (used) of start
4) Confidence 0.08 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0 Pain Relevance 0
Though there was an increase in total cholesterol and LDL-cholesterol in subjects consuming hydrogen rich water from baseline until week 8, these values were not clinically significant and were still within a normal acceptable range.
Positive_regulation (increase) of cholesterol associated with disorder of lipid metabolism
5) Confidence 0.05 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 1.15 Pain Relevance 0
Though there was an increase in total cholesterol and LDL-cholesterol in subjects consuming hydrogen rich water from baseline until week 8, these values were not clinically significant and were still within a normal acceptable range.
Positive_regulation (increase) of cholesterol associated with disorder of lipid metabolism
6) Confidence 0.05 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 1.15 Pain Relevance 0
Further, subjects demonstrated an 8% increase in high density lipoprotein (HDL)-cholesterol and a 13% decrease in total cholesterol/HDL-cholesterol from baseline to week 4.
Positive_regulation (increase) of cholesterol associated with disorder of lipid metabolism
7) Confidence 0.05 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2831093 Disease Relevance 0.95 Pain Relevance 0
However, the START study showed that the incidence of serious infections in the 10 mg/kg group increased in the 22-week period after the start of treatment [5].
Positive_regulation (increased) of start associated with infection
8) Confidence 0.01 Published 2009 Journal Mod Rheumatol Section Body Doc Link PMC2759008 Disease Relevance 0.45 Pain Relevance 0.31
The patients showed higher levels of timol test, cholesterol, LDL-cholesterol, coefficient LDL/HDL-cholesterol, beta-lipoproteins, total lipids, gamma-GTP, ASAT and lower levels of leucocytes, bilirubin, SMC, alkaline phosphatase and LAP than the other patients with cholestasis.
Positive_regulation (levels) of LDL-cholesterol in leucocytes associated with gallstones and disorder of lipid metabolism
9) Confidence 0.00 Published 1989 Journal Vutr Boles Section Abstract Doc Link 2633477 Disease Relevance 1.41 Pain Relevance 0.39

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