INT275875

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 3.87
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Aes)
Aes (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 7 98.56 Very High Very High Very High
Ziconotide 240 97.60 Very High Very High Very High
withdrawal 5 97.28 Very High Very High Very High
Central nervous system 4 96.84 Very High Very High Very High
Opioid 50 90.08 High High
Breakthrough pain 38 86.24 High High
Lasting pain 19 83.08 Quite High
Pain 49 79.88 Quite High
backache 2 74.88 Quite High
headache 7 71.92 Quite High
Disease Link Frequency Relevance Heat
Confusion 18 100.00 Very High Very High Very High
Cognitive Disorder 15 100.00 Very High Very High Very High
Dizziness 18 99.92 Very High Very High Very High
Congenital Anomalies 3 99.48 Very High Very High Very High
Vomiting 24 99.32 Very High Very High Very High
Aphasia 2 99.08 Very High Very High Very High
Depression 2 98.56 Very High Very High Very High
Catatonia 1 97.32 Very High Very High Very High
Opiate Addiction 2 97.28 Very High Very High Very High
Encephalopathy 1 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neurocognitive AEs, such as confusion, disorientation, memory impairment, speech difficulties, impaired concentration, mental slowing, or thought abnormalities, are the most troublesome of the ziconotide-related CNS AEs and, if not manageable by dose reduction, often required drug discontinuation.38
Negative_regulation (impaired) of Localization (slowing) of AEs associated with cognitive disorder, congenital anomalies, ziconotide, central nervous system and confusion
1) Confidence 0.19 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710384 Disease Relevance 2.19 Pain Relevance 0.80
All of the serious AEs were considered to be unrelated to study medication by the investigators, with one exception (drug withdrawal syndrome).34
Negative_regulation (unrelated) of Localization (All) of AEs associated with withdrawal
2) Confidence 0.02 Published 2010 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2901636 Disease Relevance 1.68 Pain Relevance 1.00

General Comments

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