INT275878

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.54
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Aes)
Aes (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Ziconotide 480 99.84 Very High Very High Very High
nud 3 96.60 Very High Very High Very High
analgesia 36 95.20 Very High Very High Very High
depression 18 93.20 High High
Pain 106 90.56 High High
Chronic nonmalignant pain 2 87.24 High High
Opioid 73 82.32 Quite High
intrathecal 208 77.96 Quite High
abdominal pain 5 74.08 Quite High
withdrawal 9 70.44 Quite High
Disease Link Frequency Relevance Heat
Infection 12 99.68 Very High Very High Very High
Volume Depletion And Dehydration 6 99.12 Very High Very High Very High
Vomiting 33 98.78 Very High Very High Very High
Dyspepsia 3 96.60 Very High Very High Very High
Gallstones 1 95.40 Very High Very High Very High
Cholecystitis 1 94.40 High High
Depression 8 93.20 High High
Toxicity 17 92.72 High High
Incontinence 1 92.60 High High
Delirium 3 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seven patients were not evaluable for response as they do not receive at least three cycles: three died (two because of unknown reasons and one because of an infection), two patients because of AEs and two because of a decrease in ECOG performance status.
Positive_regulation (because) of Gene_expression (two) of AEs associated with infection
1) Confidence 0.23 Published 2010 Journal Br J Cancer Section Body Doc Link PMC2883700 Disease Relevance 0.46 Pain Relevance 0
g/hour, respectively, due to AEs.38
Positive_regulation (due) of Gene_expression (respectively) of AEs
2) Confidence 0.22 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710384 Disease Relevance 1.98 Pain Relevance 1.32
One patient (patient 1) reported AEs (nausea and vomiting with dehydration) during treatment with ziconotide, but the AEs were considered unrelated to ziconotide therapy.49
Positive_regulation (unrelated) of Gene_expression (considered) of AEs associated with ziconotide, volume depletion and dehydration and vomiting
3) Confidence 0.22 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710384 Disease Relevance 0.79 Pain Relevance 1.60
No remedial action was deemed necessary in these three patients who recovered from these AEs.
Positive_regulation (recovered) of Gene_expression (recovered) of AEs
4) Confidence 0.04 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948431 Disease Relevance 1.31 Pain Relevance 0.48

General Comments

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