INT275878

Context Info Confidence 0.23 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 4.54 Pain Relevance 3.39

nucleus (Aes)

Aes (Rattus norvegicus)

Pain Link Frequency Relevance Heat Ziconotide 480 99.84 nud 3 96.60 analgesia 36 95.20 depression 18 93.20 Pain 106 90.56 Chronic nonmalignant pain 2 87.24 Opioid 73 82.32 intrathecal 208 77.96 abdominal pain 5 74.08 withdrawal 9 70.44

Disease Link Frequency Relevance Heat Infection 12 99.68 Volume Depletion And Dehydration 6 99.12 Vomiting 33 98.78 Dyspepsia 3 96.60 Gallstones 1 95.40 Cholecystitis 1 94.40 Depression 8 93.20 Toxicity 17 92.72 Incontinence 1 92.60 Delirium 3 91.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Seven patients were not evaluable for response as they do not receive at least three cycles: three died (two because of unknown reasons and one because of an infection), two patients because of AEs and two because of a decrease in ECOG performance status.

Positive_regulation (because) of Gene_expression (two) of AEs associated with infection

1) Confidence 0.23 Published 2010 Journal Br J Cancer Section Body Doc Link PMC2883700 Disease Relevance 0.46 Pain Relevance 0

g/hour, respectively, due to AEs.38

Positive_regulation (due) of Gene_expression (respectively) of AEs

2) Confidence 0.22 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710384 Disease Relevance 1.98 Pain Relevance 1.32

One patient (patient 1) reported AEs (nausea and vomiting with dehydration) during treatment with ziconotide, but the AEs were considered unrelated to ziconotide therapy.49

Positive_regulation (unrelated) of Gene_expression (considered) of AEs associated with ziconotide, volume depletion and dehydration and vomiting

3) Confidence 0.22 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710384 Disease Relevance 0.79 Pain Relevance 1.60

No remedial action was deemed necessary in these three patients who recovered from these AEs.

Positive_regulation (recovered) of Gene_expression (recovered) of AEs

4) Confidence 0.04 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948431 Disease Relevance 1.31 Pain Relevance 0.48

General Comments

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