INT275892

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.40
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
endothelial cells 6
tube 2
fat 2
HBA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 6 93.32 High High
Inflammatory response 11 77.96 Quite High
fibrosis 8 51.76 Quite High
ischemia 12 23.04 Low Low
Nicotine 79 5.00 Very Low Very Low Very Low
imagery 56 5.00 Very Low Very Low Very Low
isoflurane 11 5.00 Very Low Very Low Very Low
positron emission tomography 10 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Thoracotomy 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hematuria 16 96.24 Very High Very High Very High
Benign Prostatic Hypertrophy 52 95.32 Very High Very High Very High
Hemorrhage 9 93.32 High High
Pressure And Volume Under Development 1 92.20 High High
Congenital Anomalies 36 87.92 High High
Angiomatosis 14 78.96 Quite High
Hypersensitivity 1 78.28 Quite High
INFLAMMATION 19 77.60 Quite High
Cancer 19 74.00 Quite High
Fibrosis 10 51.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the EPO-treated fat grafts, there were well-vascularized areas with increased expression of CD31, and numerous endothelial islets (Figure 2C and 2D middle).
Positive_regulation (increased) of Gene_expression (expression) of CD31 in fat
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.62 Pain Relevance 0.24
Donohue and associates published their experience with 64 men scheduled to undergo TURP who were randomized to receive either 5 mg of finasteride or placebo daily for 2 weeks prior to surgery.23 Sections of prostatic urothelium were stained for VEGF expression and for CD31 to assess microvessel density (MVD) (an indicator of prostatic angiogenesis in patients with hematuria secondary to BPH).
Positive_regulation (stained) of Gene_expression (expression) of CD31 associated with benign prostatic hypertrophy and hematuria
2) Confidence 0.25 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710385 Disease Relevance 0.95 Pain Relevance 0
In order to study the phenotype of CD31+ cells thus obtained, we confirmed the endothelial phenotype of our CD31+ twice-purified hESC-ECs by flow cytometry analysis for the expression of vWF, CD31, and VE-cadherin (BD Biosciences), DiI-ac-LDL uptake assay, and Matrigel tube formation assay as previously described [15].


Positive_regulation (purified) of Gene_expression (expression) of CD31 in tube
3) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737633 Disease Relevance 0.08 Pain Relevance 0
CD31/CD144 expression increased swiftly to 10–15% after subculture in collagen as confirmed by FACS analysis, as compared to only 1–2% using the conventional EB culturing technique (Figure 1D).
Positive_regulation (increased) of Gene_expression (expression) of CD31
4) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
In order to define at a molecular level the changes occurring at each stage of hESC differentiation into endothelial cells, we next performed transcriptional profiling using whole human genome microarrays on (i) undifferentiated hESCs, (ii) day-12 EBs, (iii) hESC-ECs after CD31/CD144 sort, and (iv) HUVECs as positive control (n?
Positive_regulation (after) of Gene_expression (sort) of CD31 in endothelial cells
5) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
Immunohistochemical studies, especially those focusing on CD31 (an endothelial marker), CD34 (expressed by blood vascular endothelial cells), D2-40 and LYVE-1 (lymphatic endothalial cells), markers of vascular proliferation such as the MIB1 proliferative index and VEGF expression within the lesions, would appear to be more useful for subdividing, or on the contrary uniting, these pathological entities.
Positive_regulation (focusing) of Gene_expression (expressed) of CD31 in endothelial cells
6) Confidence 0.04 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2830950 Disease Relevance 0.36 Pain Relevance 0
Immunohistochemical studies, especially those focusing on CD31 (an endothelial marker), CD34 (expressed by blood vascular endothelial cells), D2-40 and LYVE-1 (lymphatic endothalial cells), markers of vascular proliferation such as the MIB1 proliferative index and VEGF expression within the lesions, would appear to be more useful for subdividing, or on the contrary uniting, these pathological entities.
Positive_regulation (focusing) of Gene_expression (expression) of CD31 in endothelial cells
7) Confidence 0.04 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2830950 Disease Relevance 0.40 Pain Relevance 0

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