INT27590

Context Info Confidence 0.36 First Reported 1989 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 2.38 Pain Relevance 2.26

peptidase activity (Phex) Golgi apparatus (Phex) endoplasmic reticulum (Phex)

Phex (Mus musculus)

Pain Link Frequency Relevance Heat rapifen 5 100.00 Versed 5 100.00 Paracetamol 14 99.32 Pain 4 99.26 isoflurane 5 99.10 Analgesic 8 87.92 anesthesia 3 84.56 metalloproteinase 1 76.32 depression 1 63.92 Lasting pain 1 60.60

Disease Link Frequency Relevance Heat Pain 6 99.26 Anxiety Disorder 6 99.08 Targeted Disruption 171 96.80 Body Weight 3 92.20 Post-operative Nausea 3 91.08 Vomiting 1 90.84 Toxicity 8 87.20 Stroke 1 84.48 Stress 4 77.12 Sleep Disorders 4 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Operative data and postoperative course of this initial series were compared to a contemporary population of patients (n = 119) clinically similar except that they declined HYP or were judged unsuitable for it, and who were therefore operated on under general anesthesia (GA).

Negative_regulation (declined) of HYP

1) Confidence 0.36 Published 1999 Journal J Altern Complement Med Section Body Doc Link 10630345 Disease Relevance 0 Pain Relevance 0

The protective effect of PEX (s.c. and p.o.) is more pronounced when this agent is introduced one hour before AAP (i.p. and p.o.), compared with the simultaneous administration, and when it is applied orally, compared with the subcutaneous administration.

Negative_regulation (effect) of PEX associated with paracetamol

2) Confidence 0.25 Published 1989 Journal Acta Physiol Pharmacol Bulg Section Abstract Doc Link 2634905 Disease Relevance 0.25 Pain Relevance 1.15

This reduction in anxiety and pain were achieved despite a significant reduction in intraoperative requirements for midazolam and alfentanil in the HYP group (alfentanil: 8.7 +/- 0.9 microg kg(-1)/h(-1) vs. 19.4 +/- 2 microg kg(-1)/h(-1), P < 0.001; midazolam: 0.04 +/- 0.003 mg kg(-1)/h(-1) vs. 0.09 +/- 0.01 mg kg(-1)/h(-1), P < 0.001).

Negative_regulation (reduction) of HYP associated with rapifen, pain, versed and anxiety disorder

3) Confidence 0.13 Published 1997 Journal Pain Section Abstract Doc Link 9469526 Disease Relevance 1.45 Pain Relevance 0.74

Isoflurane caused significant (P < .05) dose-dependent reduction in Q, SV, SAP, DAP, and MAP in the PRE, HYP, and SUP dogs.

Negative_regulation (reduction) of HYP associated with isoflurane

4) Confidence 0.01 Published 1996 Journal Vet Surg Section Abstract Doc Link 8928395 Disease Relevance 0.16 Pain Relevance 0.32

This metalloendopeptidase is inhibited by phosphoramidon and thiorphan [149].

Negative_regulation (inhibited) of metalloendopeptidase

5) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.52 Pain Relevance 0.04

General Comments

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