INT27591

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1987
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 30
Total Number 32
Disease Relevance 17.03
Pain Relevance 5.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) extracellular space (Alb) extracellular region (Alb)
enzyme binding (Alb) DNA binding (Alb) protein complex (Alb)
Anatomy Link Frequency
liver 10
plasma 4
Hepatocyte 4
blood 2
leukocyte 2
Alb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 75 99.98 Very High Very High Very High
Inflammatory response 76 99.76 Very High Very High Very High
lidocaine 6 99.20 Very High Very High Very High
antagonist 12 98.20 Very High Very High Very High
qutenza 2 97.52 Very High Very High Very High
Inflammation 40 95.76 Very High Very High Very High
depression 11 95.60 Very High Very High Very High
anesthesia 23 95.32 Very High Very High Very High
abdominal pain 2 89.92 High High
alcohol 4 89.36 High High
Disease Link Frequency Relevance Heat
Cancer 71 100.00 Very High Very High Very High
Albuminuria 37 100.00 Very High Very High Very High
Ovarian Cancer 3 100.00 Very High Very High Very High
Metastasis 1 100.00 Very High Very High Very High
Thrombocytopenia 13 99.92 Very High Very High Very High
Liver Disease 15 99.44 Very High Very High Very High
Hypertension 44 99.28 Very High Very High Very High
Diabetes Mellitus 213 98.96 Very High Very High Very High
Hyperammonemia 6 98.72 Very High Very High Very High
Non-small-cell Lung Cancer 66 98.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Single exposures to halothane (groups II and III) resulted in a decrease in albumin synthesis immediately or 24 h later that did not differ significantly from controls (group I).
Negative_regulation (decrease) of Gene_expression (synthesis) of albumin associated with halothane
1) Confidence 0.58 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3354889 Disease Relevance 0.08 Pain Relevance 0.88
Similarly, reduction of albumin synthesis in intact rats immediately after a second halothane exposure may indicate a response to halothane, rather than to halothane metabolites.
Negative_regulation (reduction) of Gene_expression (synthesis) of albumin associated with halothane
2) Confidence 0.58 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3354889 Disease Relevance 0.09 Pain Relevance 0.83
Halothane decreases albumin and transferrin synthesis: studies in the isolated, perfused rat liver and in the intact rat.
Negative_regulation (decreases) of Gene_expression (synthesis) of albumin in liver associated with halothane
3) Confidence 0.58 Published 1988 Journal Anesthesiology Section Title Doc Link 3354889 Disease Relevance 0 Pain Relevance 0.54
At 5 times therapeutic plasma concentrations, albumin synthesis was inhibited 40% (ibuprofen), 35% (flurbiprofen) and 100% (butibufen) after 6 h exposure and significant effects were also observed after 24 h exposure. 5.
Negative_regulation (inhibited) of Gene_expression (synthesis) of albumin in plasma
4) Confidence 0.57 Published 1988 Journal Xenobiotica Section Abstract Doc Link 3420949 Disease Relevance 0.15 Pain Relevance 0.07
It has been previously demonstrated that patients with advanced cancer have an important energy expenditure caused by increased tumor metabolism [41] and specifically in patients with NSCLC, also by means of chronic airway limitation [42] Therefore, serum albumin levels can be modified by tumor activity via increased FCR, but also by decreasing albumin synthesis, given that the majority of the time, patients with NSCLC display decreased appetite [43] and diminish their food intake [44].
Negative_regulation (decreasing) of Gene_expression (synthesis) of albumin associated with non-small-cell lung cancer and cancer
5) Confidence 0.46 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2843671 Disease Relevance 1.16 Pain Relevance 0.11
Analbuminemic (NAR) rats which are Sprague-Dawley mutants with trace levels of plasma albumin due to a defect in albumin synthesis were studied.
Negative_regulation (defect) of Gene_expression (synthesis) of albumin in plasma
6) Confidence 0.43 Published 1987 Journal J. Surg. Res. Section Abstract Doc Link 3695456 Disease Relevance 0.86 Pain Relevance 0.13
However, halothane given twice to rats at 24-h intervals (group IV) reduced their mean albumin synthesis rate to half that of controls.
Negative_regulation (reduced) of Gene_expression (synthesis) of albumin associated with halothane
7) Confidence 0.42 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3354889 Disease Relevance 0.09 Pain Relevance 0.88
Urea production did not differ in the two treatment groups, but halothane depressed albumin and transferrin synthesis 43% and 45%, respectively.
Negative_regulation (depressed) of Gene_expression (synthesis) of albumin associated with halothane
8) Confidence 0.42 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3354889 Disease Relevance 0 Pain Relevance 0.51
We found that the nursing home group was characterized by decreased levels of albumin, by increased total levels of the measured amino acids, and by increased levels of the nonessential amino acids.
Negative_regulation (decreased) of Gene_expression (levels) of albumin
9) Confidence 0.42 Published 1989 Journal J Geriatr Psychiatry Neurol Section Abstract Doc Link 2635018 Disease Relevance 0.12 Pain Relevance 0.12
Montelukast had no effect in the extrapulmonary airways but abolished albumin extravasation in the intrapulmonary airways of RSV-infected rats, with a larger effect in weanlings than in adults.
Negative_regulation (abolished) of Gene_expression (extravasation) of albumin associated with respiratory syncytial virus
10) Confidence 0.42 Published 2002 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 11943681 Disease Relevance 0.79 Pain Relevance 0.32
A significant inhibition of albumin extravasation was seen following lidocaine (P less than 0.001) or bupivacaine (P less than 0.001) treatment compared with treatment with isotonic saline.
Negative_regulation (inhibition) of Gene_expression (extravasation) of albumin associated with lidocaine
11) Confidence 0.42 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3195759 Disease Relevance 0.24 Pain Relevance 0.56
Besides, albumin synthesis may diminish with SIR found in patients with advanced NSCLC [18].
Spec (may) Negative_regulation (diminish) of Gene_expression (synthesis) of albumin associated with inflammatory response and non-small-cell lung cancer
12) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2843671 Disease Relevance 1.53 Pain Relevance 0.22
This is mainly because hepatic synthesis of albumin tends to decrease in end-stage liver disease [20].
Negative_regulation (decrease) of Gene_expression (synthesis) of albumin in liver associated with liver disease
13) Confidence 0.34 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.31 Pain Relevance 0.04
It has been previously demonstrated that patients with advanced cancer have an important energy expenditure caused by increased tumor metabolism [41] and specifically in patients with NSCLC, also by means of chronic airway limitation [42] Therefore, serum albumin levels can be modified by tumor activity via increased FCR, but also by decreasing albumin synthesis, given that the majority of the time, patients with NSCLC display decreased appetite [43] and diminish their food intake [44].
Negative_regulation (decreasing) of Gene_expression (synthesis) of albumin associated with non-small-cell lung cancer and cancer
14) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2843671 Disease Relevance 1.18 Pain Relevance 0.11
Albumin is a powerful extracellular antioxidant [36] and its decreased liver synthesis after portacaval shunt reduces its antioxidant functions.
Negative_regulation (decreased) of Gene_expression (synthesis) of Albumin in liver
15) Confidence 0.34 Published 2008 Journal Comp Hepatol Section Body Doc Link PMC2262055 Disease Relevance 0.73 Pain Relevance 0.19
BV caused a detectable increase in blood creatine kinase, glutamic oxaloacetic transaminase, and lactic dehydrogenase, as well as a decrease in the blood total protein albumin and globulin levels.
Negative_regulation (decrease) of Gene_expression (levels) of albumin in blood
16) Confidence 0.34 Published 2008 Journal Am. J. Chin. Med. Section Abstract Doc Link 18543385 Disease Relevance 0.13 Pain Relevance 0.09
However, albumin expression in the extravascular space was significantly reduced by 63.5% in IVTA-treated diabetic retinas compared with that in sham-treated diabetic retinas (6.27 ± 0.46 vs. 17.20 ± 1.78 IAU, P < 0.0001) (Fig. 4D).
Negative_regulation (reduced) of Gene_expression (expression) of albumin in retinas associated with diabetes mellitus
17) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.71 Pain Relevance 0
The levels of the following parameters were determined: hepatic reduced glutathione, serum ALT and AST, hepatic lipid peroxides, hepatic vitamin C, hepatic and serum total protein, serum albumin, serum sialic acid, serum nitrite, and serum and hepatic total LDH activities and LDH isoenzymes.
Negative_regulation (reduced) of Gene_expression (glutathione) of albumin
18) Confidence 0.25 Published 2010 Journal Scientia Pharmaceutica Section Abstract Doc Link PMC3007612 Disease Relevance 0.35 Pain Relevance 0
The obtained data revealed that CCl4 injection produced a significant decrease in reduced glutathione content, vitamin C, total protein and albumin levels.
Negative_regulation (decrease) of Gene_expression (produced) of albumin
19) Confidence 0.25 Published 2010 Journal Scientia Pharmaceutica Section Abstract Doc Link PMC3007612 Disease Relevance 0.29 Pain Relevance 0
Hepatocyte monolayers exhibited a decrease in albumin production by approximately 65% over the 12 day observation period (Figure 4B). 25K rLSEC-Hepatocyte samples exhibited a decrease of approximately 16% and 50K rLSEC-Hepatocyte cultures exhibited an increase of 28%.
Negative_regulation (decrease) of Gene_expression (production) of albumin in Hepatocyte
20) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980491 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox