INT275923

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 6
Total Number 25
Disease Relevance 13.31
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lat) plasma membrane (Lat) intracellular (Lat)
Anatomy Link Frequency
tails 1
T-cell 1
Lat (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 35 94.28 High High
adenocard 15 33.80 Quite Low
monoamine 20 27.36 Quite Low
ketamine 40 5.00 Very Low Very Low Very Low
Pain 20 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 1780 99.84 Very High Very High Very High
Sprains And Strains 900 99.60 Very High Very High Very High
Shock 20 93.24 High High
Targeted Disruption 5 93.00 High High
Infection 220 90.24 High High
Thrombosis 5 88.28 High High
Hemorrhage 5 87.00 High High
Herpes Simplex Virus 20 81.04 Quite High
Disseminated Intravascular Coagulation 10 80.36 Quite High
Repression 20 34.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of LAT, a limited degree of tyrosine phosphorylation activation of PLC?
Neg (absence) Gene_expression (absence) of LAT
1) Confidence 0.59 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.15 Pain Relevance 0
In the absence of LAT, the doseĀ–response curve was moved approximately tenfold to the right, such that a concentration of 10 ?
Neg (absence) Gene_expression (absence) of LAT
2) Confidence 0.53 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.17 Pain Relevance 0.05
Further, mutation of the site of interaction of Gads with LAT reduces signaling through the T-cell receptor by approximately 50% [28] in contrast to the full inhibition of T-cell signaling that is observed in the absence of LAT and SLP-76 [7,8].
Neg (absence) Gene_expression (absence) of LAT in T-cell
3) Confidence 0.53 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
This reduction is most likely due to increased accessibility of tyrosine residues in Syk to protein tyrosine phosphatases in the absence of LAT.
Neg (absence) Gene_expression (absence) of LAT
4) Confidence 0.53 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.18 Pain Relevance 0
This is illustrated by the role of the membrane adapter LAT and the two cytosolic adapters, Gads (Mona/Grap2/GrpL/Grf40) and SLP-76 in regulation of PLC?
Gene_expression (role) of LAT
5) Confidence 0.51 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
Primer and probe sequences used for LAT 5?
Gene_expression (used) of LAT 5
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0 Pain Relevance 0
To determine whether chromatin remodeling of the LAT region is a consistent event potentially associated with HSV-1 reactivation, regardless of the reactivation stimulus applied, we assessed the H3K4me2 enrichment of the LAT 5?
Gene_expression (enrichment) of LAT 5 associated with cold sores
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.74 Pain Relevance 0
However, the exact mechanism of the LAT in reactivation of HSV-1 has yet to be elucidated.
Gene_expression (mechanism) of LAT associated with cold sores
8) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 1.07 Pain Relevance 0
In contrast, when the same experimental protocol was applied to rabbits latent with HSV-1 strain KOS, with the goal being to determine whether we could observe a difference in the patterns of enrichment of H3K4me2 associated with the LAT region of KOS following TCIE of latently infected rabbits, we found no significant change (either increase or decrease) in the overall enrichment of H3K4me2 for the LAT 5?
Neg (no) Gene_expression (overall) of LAT 5 associated with cold sores and sprains and strains
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.94 Pain Relevance 0
Previous studies identified changes in the acetyl-H3K9K14 associated with the LAT and IE regions of HSV-1 following the application of a reactivation stimulus in mice [19], [59].
Gene_expression (regions) of LAT associated with cold sores
10) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.32 Pain Relevance 0
Changes to Euchromatin on LAT and ICP4 Following Reactivation Are More Prevalent in an Efficiently Reactivating Strain of HSV-1

Background

Gene_expression (Changes) of LAT associated with cold sores and sprains and strains
11) Confidence 0.43 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2973973 Disease Relevance 0.75 Pain Relevance 0
Therefore, our results show that the LAT 5?
Gene_expression (show) of LAT 5
12) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.82 Pain Relevance 0
We hypothesize that the LAT 5?
Spec (hypothesize) Gene_expression (hypothesize) of LAT 5
13) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.58 Pain Relevance 0
To determine whether chromatin remodeling of the LAT region is a consistent event potentially associated with HSV-1 reactivation, regardless of the reactivation stimulus applied, we assessed the H3K4me2 enrichment of the LAT 5?
Gene_expression (region) of LAT associated with cold sores
14) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.77 Pain Relevance 0
During latency the LAT 5?
Gene_expression (During) of LAT 5
15) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.64 Pain Relevance 0
In order to answer this question and to begin to define the potential of epigenetic changes to the HSV-1 genome as a function of the reactivation process, we outlined studies with the following objectives: 1) to stimulate HSV-1 reactivation in an animal model using an efficient reactivation method not capable of directly modify histone tails; 2) to determine whether changes in the enrichment of a euchromatic histone marker could be observed for the LAT and IE regions of HSV-1 following reactivation stimuli; 3) to correlate any changes in the enrichments of euchromatic marks to LAT and lytic transcript abundance; and 4) to determine whether wild-type HSV-1 strains with different reactivation phenotypes established dissimilar profiles of euchromatic marker enrichments on the LAT and IE regions during latency and/or following the application of a reactivation stimulus.
Gene_expression (regions) of LAT in tails associated with cold sores and sprains and strains
16) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.86 Pain Relevance 0
Unlike the consistent decrease in LAT transcription following iontophoresis, the RNA abundance of the ICP4 region is transient in nature, leading us to further speculate that LAT remodeling and the subsequent decreased LAT transcription facilitate the transient increase in lytic transcript abundance, and that chromatin remodeling of the LAT may ultimately be responsible for events leading to in vivo reactivation.
Gene_expression (remodeling) of LAT
17) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.37 Pain Relevance 0
It has been suggested that the LAT 5?
Gene_expression (suggested) of LAT 5
18) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.67 Pain Relevance 0
The H3 K4me2 enrichment and RNA abundance of the LAT 5?
Gene_expression (enrichment) of LAT 5
19) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 1.00 Pain Relevance 0
Further, the LAT 5?
Gene_expression (Further) of LAT 5
20) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.70 Pain Relevance 0

General Comments

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