INT275931

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Grb2) endosome (Grb2) anatomical structure formation involved in morphogenesis (Grb2)
aging (Grb2) Golgi apparatus (Grb2) nucleus (Grb2)
Anatomy Link Frequency
SH3 2
Platelets 1
Grb2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 28 5.00 Very Low Very Low Very Low
adenocard 12 5.00 Very Low Very Low Very Low
Spinal cord 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 62 50.00 Quite Low
Repression 3 50.00 Quite Low
Hemorrhage 4 48.32 Quite Low
Thrombosis 4 46.56 Quite Low
Stress 3 26.80 Quite Low
Dementia 15 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low
Adhesions 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The strong binding of Grb2 to LAT is explained by the presence of three sites for association of Grb2 with LAT at phosphotyrosines Y171, Y191, and Y226 [28,32,33], compared with a single site for Gads at phosphotyrosine Y191, and to a lesser extent Y171 [28,32,33].
Grb2 Binding (binding) of
1) Confidence 0.26 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
This is an atypical interaction, as the majority of SH3 domains bind to proline rich sequences with micromolar affinity, including the C-terminal SH3 domain of Grb2, which binds to a proline rich region in SLP-76 with an affinity of 3 ?
Grb2 Binding (binds) of in SH3
2) Confidence 0.26 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
Platelets express the Gads-related adapter, Grb2, which also binds to LAT and SLP-76.
Grb2 Binding (binds) of in Platelets
3) Confidence 0.25 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
The strong binding of Grb2 to LAT is explained by the presence of three sites for association of Grb2 with LAT at phosphotyrosines Y171, Y191, and Y226 [28,32,33], compared with a single site for Gads at phosphotyrosine Y191, and to a lesser extent Y171 [28,32,33].
Grb2 Binding (association) of
4) Confidence 0.25 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
The phosphorylated tyrosine of the target protein is bound by the SH2 domain of GRB2, which also contains an SH3 domain that binds to the proline-rich region of SOS.
GRB2 Binding (bound) of in SH3
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0 Pain Relevance 0

General Comments

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