INT275932

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Grb2) endosome (Grb2) anatomical structure formation involved in morphogenesis (Grb2)
aging (Grb2) Golgi apparatus (Grb2) nucleus (Grb2)
Anatomy Link Frequency
platelets 2
SH3 1
Grb2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 21 5.00 Very Low Very Low Very Low
adenocard 9 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhage 3 47.28 Quite Low
Thrombosis 3 45.52 Quite Low
Adhesions 6 34.76 Quite Low
Disseminated Intravascular Coagulation 6 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelets express the Gads-related adapter, Grb2, which also binds to LAT and SLP-76.
Gene_expression (express) of Grb2 in Platelets
1) Confidence 0.53 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
This is an atypical interaction, as the majority of SH3 domains bind to proline rich sequences with micromolar affinity, including the C-terminal SH3 domain of Grb2, which binds to a proline rich region in SLP-76 with an affinity of 3 ?
Gene_expression (domain) of Grb2 in SH3
2) Confidence 0.46 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
Gads belongs to a family of three adapters, but only one other of these is expressed in platelets, namely Grb2, which is also known to bind to LAT [28].
Gene_expression (expressed) of Grb2 in platelets
3) Confidence 0.46 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0

General Comments

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