INT275933

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Context Info
Confidence 0.51
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.07
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lat) plasma membrane (Lat) intracellular (Lat)
Anatomy Link Frequency
platelets 4
T cells 1
Lat (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 42 81.48 Quite High
anesthesia 6 35.60 Quite Low
adenocard 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 12 70.80 Quite High
Disseminated Intravascular Coagulation 12 5.00 Very Low Very Low Very Low
Thrombosis 6 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Hemorrhage 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In theory, the breeding of mice that are deficient in both Gads and LAT is required to confirm a role for Gads in the regulation of LAT in that a similar level of inhibition should be seen in mice platelets deficient in LAT to those deficient in LAT and Gads.
Negative_regulation (deficient) of LAT in platelets
1) Confidence 0.51 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
In theory, the breeding of mice that are deficient in both Gads and LAT is required to confirm a role for Gads in the regulation of LAT in that a similar level of inhibition should be seen in mice platelets deficient in LAT to those deficient in LAT and Gads.
Negative_regulation (deficient) of LAT in platelets
2) Confidence 0.45 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
For example, mice deficient in Gads have a marked reduction in mature T cells [9] as a consequence of inhibited pre-TCR signaling, whereas mice deficient in LAT and SLP-76 have no circulating T cells.
Negative_regulation (deficient) of LAT in T cells
3) Confidence 0.37 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
In theory, the breeding of mice that are deficient in both Gads and LAT is required to confirm a role for Gads in the regulation of LAT in that a similar level of inhibition should be seen in mice platelets deficient in LAT to those deficient in LAT and Gads.
Negative_regulation (deficient) of LAT in platelets
4) Confidence 0.37 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
Genetically modified mice deficient in Gads [9] and LAT [5] were bred as heterozygotes to generate knockouts and littermate controls.
Negative_regulation (deficient) of LAT
5) Confidence 0.33 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0.04
Studies were designed to monitor platelet aggregation on collagen at an arteriolar rate of flow in platelets deficient in Gads or LAT.
Negative_regulation (deficient) of LAT in platelet
6) Confidence 0.33 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.07 Pain Relevance 0

General Comments

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