INT275937

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 14
Disease Relevance 1.67
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Syk) cytoplasm (Syk)
Anatomy Link Frequency
macrophages 2
monocytes 1
THP-1 1
platelets 1
a band 1
Syk (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 96 84.32 Quite High
cytokine 120 75.28 Quite High
chemokine 36 48.00 Quite Low
agonist 14 20.64 Low Low
Inflammatory response 48 5.00 Very Low Very Low Very Low
Inflammatory mediators 24 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
headache 12 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 2 97.84 Very High Very High Very High
Hemorrhage 2 96.56 Very High Very High Very High
Apoptosis 24 93.84 High High
INFLAMMATION 168 84.32 Quite High
Rupture 36 83.36 Quite High
Adhesions 4 80.68 Quite High
Hypertension 12 66.72 Quite High
Fever 72 65.36 Quite High
Stress 12 62.92 Quite High
Infection 108 53.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then carried out anti-Syk immunoprecipitation, followed by anti phospho-tyrosine analysis and found that Syk was phosphorylated in response to Hz, but not MSU stimulation (Fig. 5B).
Phosphorylation (phosphorylated) of Syk
1) Confidence 0.54 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.23 Pain Relevance 0
The Src kinase inhibitor PP2 decreased the Hz-induced Syk phosphorylation in a dose dependent manner (Fig. 5C).
Phosphorylation (phosphorylation) of Syk
2) Confidence 0.54 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.17 Pain Relevance 0
Even by extending the time-course of stimulation, MSU did not induce Syk phosphorylation (Fig S4A).
Phosphorylation (phosphorylation) of Syk
3) Confidence 0.54 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.21 Pain Relevance 0
We also showed that the MyD88 signaling pathway is not involved in the Hz-induced Syk phosphorylation.
Phosphorylation (phosphorylation) of Syk
4) Confidence 0.54 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.35 Pain Relevance 0.15
Interestingly, a reduction in tyrosine phosphorylation of Syk was also observed in the absence of LAT in platelets stimulated by CRP and rhodocytin.
Phosphorylation (phosphorylation) of Syk in platelets
5) Confidence 0.47 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.19 Pain Relevance 0
However, MSU was previously reported to trigger Syk phosphorylation in dendritic cells [35] and human neutrophils [36], as well as Lyn phosphorylation in neutrophils [37].
Phosphorylation (phosphorylation) of Syk in neutrophils
6) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.06 Pain Relevance 0
These results rule out a possible effect of LPS on Syk phosphorylation.
Phosphorylation (phosphorylation) of Syk
7) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
In our hands, MSU did not induce Syk or Lyn phosphorylation in PMA-differentiated THP-1 cells nor in BMDM.
Phosphorylation (phosphorylation) of Syk in THP-1
8) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.06 Pain Relevance 0
To evaluate the relative roles of LPS and Hz in the induction of this signaling pathway, we treated BMDM with LPS and we observed that LPS by itself did not induce phospho-Syk, and indeed pre-treatment with LPS reduced Hz-induced Syk phosphorylation (Fig.
Phosphorylation (phosphorylation) of Syk
9) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
Consistent with the possible involvement of Syk, we observed a band with an apparent molecular weight of 72 kDa that was phosphorylated in response to Hz, but not MSU (Fig. 5A).
Phosphorylation (phosphorylated) of Syk in a band
10) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.26 Pain Relevance 0
S5C) indeed blocked, in dose-dependent manner, Syk phosphorylation in Hz-stimulated monocytes (Fig.
Phosphorylation (phosphorylation) of Syk in monocytes
11) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.05 Pain Relevance 0
Using BMDM from Lyn-deficient mice, we found that Hz-induced Syk phosphorylation required Lyn, and further confirmed that MSU does not utilize this signaling pathway in either murine or human macrophages (Fig. 5).
Phosphorylation (phosphorylation) of Syk in macrophages
12) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
Consistent with the involvement of this kinase in a pathway upstream of the inflammasome, NLRP3-, ASC- and NLRC4-deficient macrophages exhibited normal Syk phosphorylation upon Hz stimulation (Fig. 6D).
Phosphorylation (phosphorylation) of Syk in macrophages
13) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
There was a small but consistent reduction in tyrosine phosphorylation of Syk, SLP-76, and PLC?
Phosphorylation (phosphorylation) of Syk
14) Confidence 0.36 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.08 Pain Relevance 0

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