INT27596

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Context Info
Confidence 0.42
First Reported 1984
Last Reported 1996
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.47
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Anatomy Link Frequency
outflow 2
cerebral cortex 2
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 14 100.00 Very High Very High Very High
noradrenaline 7 98.28 Very High Very High Very High
cerebral cortex 1 93.80 High High
antagonist 4 90.24 High High
cva 1 86.88 High High
substance P 4 85.72 High High
agonist 6 84.24 Quite High
Serotonin 1 52.80 Quite High
Hyperesthesia 7 50.00 Quite Low
Morphine 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 2 94.92 High High
Pressure Volume 2 Under Development 1 90.56 High High
Hemorrhage 1 86.88 High High
Injury 5 57.88 Quite High
Hyperaesthesia 4 56.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clonidine inhibited, through the activation of alpha 2 presynaptic receptors, the release of [3H]noradrenaline (pIC30 = 7.47) and [3H]5-hydroxytryptamine (pIC30 = 6.47) evoked by 15 mM KCl from superfused rat cerebral cortex synaptosomes.
Negative_regulation (inhibited) of Positive_regulation (activation) of alpha 2 in cerebral cortex associated with noradrenaline, cerebral cortex and clonidine
1) Confidence 0.42 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2990964 Disease Relevance 0 Pain Relevance 0.59
Clonidine inhibits salivary secretion by activation of postsynaptic alpha 2-receptors.
Negative_regulation (inhibits) of Positive_regulation (activation) of alpha 2 associated with clonidine
2) Confidence 0.37 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 6207441 Disease Relevance 0 Pain Relevance 0.89
This suggested that the activation of spinal alpha 2 receptor may reduce the sympathetic outflow and this reduction of sympathetic outflow may be the key mechanism that delays the development of thermal hyperesthesia.


Spec (may) Negative_regulation (reduce) of Positive_regulation (activation) of alpha 2 in outflow
3) Confidence 0.34 Published 1996 Journal Anesthesiology Section Body Doc Link 8873554 Disease Relevance 0.11 Pain Relevance 0
Activation of alpha-1 and alpha-2 receptors by intraarterial injection of phenylephrine and clonidine caused a reduction in PBF in dogs and decreases in arteriolar and venular diameters and volumetric flow in rats.
Negative_regulation (decreases) of Positive_regulation (Activation) of alpha-2 associated with clonidine
4) Confidence 0.01 Published 1989 Journal Proc Finn Dent Soc Section Abstract Doc Link 2635779 Disease Relevance 0.36 Pain Relevance 0.30

General Comments

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