INT275971

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Grap2) signal transduction (Lat) nucleus (Grap2)
plasma membrane (Lat) intracellular (Lat) cytoplasm (Grap2)
Anatomy Link Frequency
T-cell 2
Platelets 1
Lat (Mus musculus)
Grap2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 21 5.00 Very Low Very Low Very Low
adenocard 9 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disseminated Intravascular Coagulation 6 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Thrombosis 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Hemorrhage 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, mutation of the site of interaction of Gads with LAT reduces signaling through the T-cell receptor by approximately 50% [28] in contrast to the full inhibition of T-cell signaling that is observed in the absence of LAT and SLP-76 [7,8].
LAT Binding (interaction) of Gads in T-cell
1) Confidence 0.24 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
Gads binds constitutively to SLP-76 and associates with LAT upon T-cell receptor (TCR) activation forming a LAT signalosome that is critical for activation of PLC?
LAT Binding (binds) of Gads in T-cell
2) Confidence 0.21 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
Platelets express the Gads-related adapter, Grb2, which also binds to LAT and SLP-76.
LAT Binding (binds) of Gads-related in Platelets
3) Confidence 0.20 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0

General Comments

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