INT275974

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Grb2) endosome (Grb2) anatomical structure formation involved in morphogenesis (Grb2)
aging (Grb2) Golgi apparatus (Grb2) intracellular (Lat)
Anatomy Link Frequency
platelets 2
Grb2 (Mus musculus)
Lat (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 35 5.00 Very Low Very Low Very Low
adenocard 15 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 10 33.52 Quite Low
Hemorrhage 5 6.24 Low Low
Disseminated Intravascular Coagulation 10 5.00 Very Low Very Low Very Low
Thrombosis 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, this is consistent with the present result, which demonstrates that Grb2 associates strongly with LAT but only weakly with SLP-76, whereas Gads is constitutively associated with SLP-76 (not shown).
Grb2 Binding (associates) of LAT
1) Confidence 0.33 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
Platelets express the Gads-related adapter, Grb2, which also binds to LAT and SLP-76.
Grb2 Binding (binds) of LAT in Platelets
2) Confidence 0.26 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
The strong binding of Grb2 to LAT is explained by the presence of three sites for association of Grb2 with LAT at phosphotyrosines Y171, Y191, and Y226 [28,32,33], compared with a single site for Gads at phosphotyrosine Y191, and to a lesser extent Y171 [28,32,33].
Grb2 Binding (binding) of LAT
3) Confidence 0.25 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
Gads belongs to a family of three adapters, but only one other of these is expressed in platelets, namely Grb2, which is also known to bind to LAT [28].
Grb2 Binding (bind) of LAT in platelets
4) Confidence 0.22 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
The strong binding of Grb2 to LAT is explained by the presence of three sites for association of Grb2 with LAT at phosphotyrosines Y171, Y191, and Y226 [28,32,33], compared with a single site for Gads at phosphotyrosine Y191, and to a lesser extent Y171 [28,32,33].
Grb2 Binding (association) of LAT
5) Confidence 0.22 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0

General Comments

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