INT275983

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.41
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lat) plasma membrane (Lat) intracellular (Lat)
cytoplasm (Lcp2)
Anatomy Link Frequency
mature T cells 2
DT40 1
T-cell 1
Lat (Mus musculus)
Lcp2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 35 91.68 High High
adenocard 15 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 5 74.64 Quite High
Hemorrhage 5 73.36 Quite High
Disseminated Intravascular Coagulation 10 5.00 Very Low Very Low Very Low
Adhesions 10 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gads binds constitutively to SLP-76 and associates with LAT upon T-cell receptor (TCR) activation forming a LAT signalosome that is critical for activation of PLC?
LAT Binding (binds) of SLP-76 in T-cell
1) Confidence 0.23 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
In comparison to LAT and SLP-76, Gads has a relatively minor role in recruiting SLP-76 to LAT and activation of PLC?
LAT Binding (recruiting) of SLP-76
2) Confidence 0.23 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.15 Pain Relevance 0.03
Indeed, it may be that the evolution of a role for Gads in mediating the interaction between LAT and SLP-76 has occurred because of its role in facilitating weak signaling by the pre-TCR to ensure an optimal number of mature T cells in the circulation rather than to facilitate TCR or platelet activation at higher agonist concentrations.
LAT Binding (interaction) of SLP-76 in mature T cells associated with agonist
3) Confidence 0.22 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.13 Pain Relevance 0.05
This raises the possibility that a role for Gads could be masked by the presence of Grb2, especially in light of studies in a DT40 cell model reporting that Gads and Grb2 are both able to couple LAT and SLP-76, albeit that Gads does this more efficiently [31].
LAT Binding (couple) of SLP-76 in DT40
4) Confidence 0.22 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
Indeed, it may be that the evolution of a role for Gads in mediating the interaction between LAT and SLP-76 has occurred because of its role in facilitating weak signaling by the pre-TCR to ensure an optimal number of mature T cells in the circulation rather than to facilitate TCR or platelet activation at higher agonist concentrations.
LAT Binding (interaction) of SLP-76 in mature T cells associated with agonist
5) Confidence 0.22 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.13 Pain Relevance 0.05

General Comments

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