INT275992

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.31
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Rpa1) nucleus (Rpa1) DNA binding (Rpa1)
cytoplasm (Rpa1)
Rpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
interneuron 3 97.04 Very High Very High Very High
long-term potentiation 12 95.24 Very High Very High Very High
GABAergic 3 89.92 High High
depression 27 77.16 Quite High
Central nervous system 6 63.96 Quite High
Dopamine 3 48.16 Quite Low
gABA 33 27.56 Quite Low
imagery 15 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 6 92.24 High High
Depression 27 77.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of RP requires a postsynaptic [Ca2+]i increase and the subsequent activation of Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) (Kano et al, 1992, 1996).
Positive_regulation (requires) of Positive_regulation (Induction) of RP
1) Confidence 0.05 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.15 Pain Relevance 0.25
Recently, we reported that mGluR1 activity supports RP induction by facilitating the PKA/phospho-DARPP-32/PP-1 inhibition pathway (Sugiyama et al, 2008).
Positive_regulation (supports) of Positive_regulation (induction) of RP
2) Confidence 0.05 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.15 Pain Relevance 0.12
Taken together, these results indicate that PDE1 inhibition substantially lowered the [Ca2+]i required for RP induction, as predicted by the simulation, indicating a critical role of PDE1 in the [Ca2+]i threshold control.
Positive_regulation (required) of Positive_regulation (induction) of RP
3) Confidence 0.05 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0

General Comments

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