INT276

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2010
Negated 15
Speculated 9
Reported most in Abstract
Documents 83
Total Number 92
Disease Relevance 16.75
Pain Relevance 25.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
brain 11
sciatic nerve 6
cerebral cortex 4
frontal cortex 4
liver 2
Ache (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 113 100.00 Very High Very High Very High
Neurotransmitter 93 100.00 Very High Very High Very High
qutenza 67 100.00 Very High Very High Very High
Morphine 46 100.00 Very High Very High Very High
anesthesia 43 100.00 Very High Very High Very High
antagonist 35 100.00 Very High Very High Very High
tetrodotoxin 33 100.00 Very High Very High Very High
electroacupuncture 32 100.00 Very High Very High Very High
Enkephalin 16 100.00 Very High Very High Very High
noradrenaline 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 206 100.00 Very High Very High Very High
INFLAMMATION 109 100.00 Very High Very High Very High
Neurodegenerative Disease 15 100.00 Very High Very High Very High
Epilepsy 7 100.00 Very High Very High Very High
Stroke 6 100.00 Very High Very High Very High
Arrhythmias 2 Under Development 4 100.00 Very High Very High Very High
Partial Seizures 1 100.00 Very High Very High Very High
Stress 17 99.84 Very High Very High Very High
Liver Failure 130 99.68 Very High Very High Very High
Urological Neuroanatomy 108 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that morphine and ethanol may be inducing changes in the feedback mechanism which regulates the levels of AChE at post-synaptic sites, and these changes could play an important role in the development of tolerance to morphine and to ethanol.
Regulation (regulates) of AChE associated with tolerance and morphine
1) Confidence 0.62 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 3683767 Disease Relevance 0 Pain Relevance 0.64
In this study, we examined comparative morphological effect on acetylcholinesterase (AChE) following intra-amygdaloid injection of db-cAMP or, kainate.
Spec (examined) Regulation (effect) of AChE
2) Confidence 0.62 Published 1990 Journal No To Shinkei Section Abstract Doc Link 2164408 Disease Relevance 0.22 Pain Relevance 0.19
In this study, we examined comparative morphological effect on acetylcholinesterase (AChE) following intra-amygdaloid injection of db-cAMP or, kainate.
Spec (examined) Regulation (effect) of acetylcholinesterase
3) Confidence 0.62 Published 1990 Journal No To Shinkei Section Abstract Doc Link 2164408 Disease Relevance 0.22 Pain Relevance 0.19
In the present work we investigated the effect of ovariectomy on acetylcholinesterase (AChE) activity and ganglioside content in cerebral cortex of female rats.
Spec (investigated) Regulation (effect) of acetylcholinesterase in cerebral cortex associated with cerebral cortex
4) Confidence 0.62 Published 2005 Journal Metab Brain Dis Section Abstract Doc Link 15918548 Disease Relevance 0.07 Pain Relevance 0.12
In the present work we investigated the effect of ovariectomy on acetylcholinesterase (AChE) activity and ganglioside content in cerebral cortex of female rats.
Spec (investigated) Regulation (effect) of AChE in cerebral cortex associated with cerebral cortex
5) Confidence 0.62 Published 2005 Journal Metab Brain Dis Section Abstract Doc Link 15918548 Disease Relevance 0.07 Pain Relevance 0.12
Effect of anesthesia on membrane fluidity and acetylcholinesterase activity in rat brain synaptosomes.
Regulation (Effect) of acetylcholinesterase in brain associated with anesthesia
6) Confidence 0.62 Published 1980 Journal Boll. Soc. Ital. Biol. Sper. Section Title Doc Link 7448016 Disease Relevance 0 Pain Relevance 0.37
Moreover, no significant alteration in the spatial distribution and the density of hippocampal dentate acetylcholinesterase reaction product was seen in ischemic animals.
Neg (no) Regulation (alteration) of acetylcholinesterase reaction product
7) Confidence 0.61 Published 1990 Journal Brain Res. Section Abstract Doc Link 2337781 Disease Relevance 0.29 Pain Relevance 0.29
However, the regulation of each AChE form and of the BuChE is probably controlled by different mechanisms (García-Ayllón et al., 2007).
Regulation (regulation) of AChE
8) Confidence 0.60 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.25 Pain Relevance 0.03
AChE levels are regulated at transcriptional, post-transcriptional and post-translational levels, leading to complex expression patterns which are modulated by physiological and pathological conditions through mechanisms that are not fully understood.
Regulation (regulated) of AChE
9) Confidence 0.60 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.16 Pain Relevance 0
Alterations in AChE activity have not been previously observed in brains of deceased cirrhotic patients, nor in portacaval-shunted rats (Rao et al., 1994).
Regulation (Alterations) of AChE in brains associated with cirrhosis
10) Confidence 0.60 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.15 Pain Relevance 0
Rivastigmine can also affect AChE activity, thus we extended our examination to include western blotting analysis.
Regulation (affect) of AChE
11) Confidence 0.60 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.13 Pain Relevance 0.03
Further studies addressing the possibility that other precipitant factors, such as manganese (Krieger et al., 1995), may contribute to cholinergic imbalance symptoms are warranted as it has been suggested that manganese may modulate cholinergic systems, including affecting AChE activity (Finkelstein et al., 2007).
Regulation (affecting) of AChE
12) Confidence 0.60 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.46 Pain Relevance 0.03
Trophic regulation of acetylcholinesterase isoenzymes in adult mammalian skeletal muscles.
Regulation (regulation) of acetylcholinesterase in skeletal muscles
13) Confidence 0.60 Published 1992 Journal Neurochem. Res. Section Title Doc Link 1311432 Disease Relevance 0 Pain Relevance 0.09
The regulation of acetylcholinesterase by cis-elements within intron I in cultured contracting myotubes.
Regulation (regulation) of acetylcholinesterase in myotubes
14) Confidence 0.59 Published 2006 Journal J. Neurochem. Section Title Doc Link 16787423 Disease Relevance 0.08 Pain Relevance 0.15
In relation to the acetylcholinesterase activity, GAA caused a significant inhibition in the activity of this enzyme in blood at concentrations of 150 and 200 microM (P < 0.05), but did not alter the acetylcholinesterase activity in synaptosomes from the cerebral cortex.
Neg (not) Regulation (alter) of acetylcholinesterase in cerebral cortex associated with cerebral cortex
15) Confidence 0.57 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18256932 Disease Relevance 0.07 Pain Relevance 0.13
[Effects of capsaicin and electroacupuncture on the fluoride resistant acid phosphatase (FRAP) and acetylcholinesterase (AChE) activities in the dorsal root ganglion (DRG) neurons of rats: a histochemical observation].
Regulation (Effects) of AChE in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, qutenza and electroacupuncture
16) Confidence 0.53 Published 1993 Journal Zhen Ci Yan Jiu Section Title Doc Link 7923716 Disease Relevance 0.69 Pain Relevance 1.35
Our data indicates that only the tetrameric AChE form, the ‘true’ cholinergic species, is affected during liver failure.
Regulation (affected) of AChE in liver associated with liver failure
17) Confidence 0.53 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.27 Pain Relevance 0.04
The results suggest that excitation-contraction is an important factor in regulation of muscle acetylcholinesterase.
Regulation (regulation) of acetylcholinesterase in muscle
18) Confidence 0.53 Published 1976 Journal Neuroscience Section Abstract Doc Link 11370230 Disease Relevance 0 Pain Relevance 0.26
Cultures of 11 day old chick embryo pectoral muscle were used to study the effects of direct electrical stimulation and neurochemicals such as acetylcholine, acetyl-beta-methylcholine, tetrodotoxin, and d-tubocurarine on the acetylcholinesterase levels of muscle.
Regulation (effects) of acetylcholinesterase in embryo associated with tetrodotoxin
19) Confidence 0.53 Published 1976 Journal Neuroscience Section Abstract Doc Link 11370230 Disease Relevance 0 Pain Relevance 0.24
Regulation of acetylcholinesterase in cultured muscle by chemical agents and electrical stimulation.
Regulation (Regulation) of acetylcholinesterase in muscle
20) Confidence 0.53 Published 1976 Journal Neuroscience Section Title Doc Link 11370230 Disease Relevance 0 Pain Relevance 0.24

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