INT276012

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Context Info
Confidence 0.66
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.58
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde1b) nucleus (Pde1b) cytoplasm (Pde1b)
Anatomy Link Frequency
neurons 3
central nervous system 1
Pde1b (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 14 99.68 Very High Very High Very High
Glutamate receptor 7 77.24 Quite High
Serotonin 7 75.32 Quite High
long-term potentiation 28 75.04 Quite High
dopamine receptor 7 74.88 Quite High
imagery 35 65.20 Quite High
Pyramidal cell 7 64.00 Quite High
depression 63 50.68 Quite High
Bioavailability 1 50.24 Quite High
gABA 77 33.20 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 66 99.22 Very High Very High Very High
Disease 17 96.16 Very High Very High Very High
Apoptosis 2 77.52 Quite High
Depression 63 50.68 Quite High
Hypoxia 4 44.96 Quite Low
Renal Insufficiency 1 25.28 Quite Low
Adhesions 14 16.08 Low Low
Cirrhosis 1 12.48 Low Low
Increased Venous Pressure Under Development 5 6.00 Low Low
Cv General 4 Under Development 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDE1B is highly expressed in Purkinje neurons (Yu et al, 1997).
Gene_expression (expressed) of PDE1B in neurons
1) Confidence 0.66 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.05 Pain Relevance 0.17
PDE1 is widely expressed in the central nervous system (Polli and Kincaid, 1994; Yu et al, 1997).
Gene_expression (expressed) of PDE1 in central nervous system associated with central nervous system
2) Confidence 0.66 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.09
In addition, we showed that the CaMKII-mediated reduction of PDE1 affinity with Ca2+/CaM forms another positive-feedback loop.
Gene_expression (reduction) of PDE1
3) Confidence 0.57 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Thus, the [Ca2+]i threshold required for the sustained CaMKII activation was markedly lowered by PDE1 reduction.
Gene_expression (reduction) of PDE1
4) Confidence 0.57 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Verification of PDE1-mediated control of the [Ca2+]i threshold for RP induction
Gene_expression (Verification) of PDE1
5) Confidence 0.57 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.03
To incorporate the cAMP regulation, here we have added PDE1 and PDE4 (both of which are expressed in Purkinje neurons, see Supplementary Figure 1) to the simulation model.
Gene_expression (expressed) of PDE1 in neurons
6) Confidence 0.57 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
As shown in Supplementary Figure 1, PDE1B was highly expressed in Purkinje neurons (Polli and Kincaid, 1994; Yu et al, 1997).
Gene_expression (expressed) of PDE1B in neurons
7) Confidence 0.51 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
One study comparing sildenafil to inhaled NO (iNO) demonstrated comparable reductions in PA pressures and pulmonary vascular resistance (PVR), but increased cardiac index (CI) was seen only with sildenafil treatment, consistent with an inotropic effect.24 However, other investigators, examining load-independent measures of myocardial performance, found no changes in systolic or diastolic function with sildenafil treatment.25 Circulating endothelial progenitor cells are reduced in idiopathic PAH and congenital PAH, and treatment with sildenafil has been shown to increase these cells to levels consistently higher than other PAH therapies.26 Sildenafil also inhibits PDE-1, which is expressed in low levels in the pulmonary circulation under baseline conditions but is upregulated in the disease state.27 The clinical significance of these findings remains uncertain.
Gene_expression (expressed) of PDE-1 associated with pulmonary hypertension and disease
8) Confidence 0.17 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2880338 Disease Relevance 0.53 Pain Relevance 0.03

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