INT276014

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.08
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Rpa1) nucleus (Rpa1) DNA binding (Rpa1)
cytoplasm (Rpa1)
Rpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 4 92.80 High High
Dopamine 6 71.28 Quite High
gABA 50 58.96 Quite High
Glutamate 49 50.00 Quite Low
potassium channel 1 49.04 Quite Low
long-term potentiation 16 39.32 Quite Low
GABAergic 16 37.52 Quite Low
depression 36 21.24 Low Low
imagery 23 5.00 Very Low Very Low Very Low
Central nervous system 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 4 80.56 Quite High
Depression 36 21.24 Low Low
Adhesions 8 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Poisoning 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Blister 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The synergistic action of CaMKII autophosphorylation at Thr286/287 and PDE1 inhibition by CaMKII underlies the state switching of molecular networks regulating RP.
Regulation (regulating) of RP
1) Confidence 0.04 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.05
The biological significance of the double staining for each of the mentioned pairs (ET, cell marker) was determined by calculating the Pearson's correlation coefficient (rp) for each analyzed region of interest (ROI) in multiple slices.
Spec (determined) Regulation (calculating) of rp
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.08 Pain Relevance 0
Altogether, the kinetic simulation model for the RP regulation includes two feedforward inhibitory pathways (PDE1 and calcineurin pathways) and two positive-feedback loops (autophosphorylation of CaMKII Thr286/287 and inhibition of PDE1 by CaMKII).
Regulation (regulation) of RP
3) Confidence 0.03 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.03
To address this issue, we developed a kinetic simulation model of the molecular network and systematically analyzed the behavior of signaling cascades regulating RP.
Spec (analyzed) Regulation (regulating) of RP
4) Confidence 0.02 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.04
A kinetic simulation model of signaling cascades regulating RP was constructed based on our earlier study (Kawaguchi and Hirano, 2002) with slight modification (Figure 1A).
Regulation (regulating) of RP
5) Confidence 0.02 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0

General Comments

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