INT276033

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ppp1cc, Ppp1r1b) nucleus (Ppp1cc, Ppp1r1b) mitochondrion (Ppp1cc)
intracellular (Ppp1r1b) carbohydrate metabolic process (Ppp1cc) protein complex (Ppp1cc)
Ppp1cc (Mus musculus)
Ppp1r1b (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 1 62.96 Quite High
Serotonin 1 61.04 Quite High
dopamine receptor 1 60.60 Quite High
Pyramidal cell 1 49.72 Quite Low
depression 9 36.40 Quite Low
gABA 11 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
long-term potentiation 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
interneuron 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 9 36.40 Quite Low
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It produces a positive-feedback loop in the molecular network, because PDE1 inhibition increases the intracellular cAMP concentration, thus promoting the PKA activity, which in turn supports the CaMKII activity through inhibition of PP-1 by phospho-DARPP-32.
PP-1 Neg (inhibition) Binding (inhibition) of phospho-DARPP-32
1) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.09

General Comments

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