INT276046

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Context Info
Confidence 0.15
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.11
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Prkaca, Ppp1r1b) nucleus (Prkaca, Ppp1r1b) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) intracellular (Ppp1r1b) protein complex (Prkaca)
Prkaca (Mus musculus)
Ppp1r1b (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1 99.92 Very High Very High Very High
long-term potentiation 4 74.24 Quite High
GABAergic 1 68.92 Quite High
depression 9 56.16 Quite High
Central nervous system 2 20.72 Low Low
gABA 11 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
interneuron 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 9 56.16 Quite High
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of PKA activity facilitates calcineurin (a Ca2+-activated protein phosphatase, also called PP2B)-mediated dephosphorylation of DARPP-32 (dopamine and cAMP-regulated phosphoprotein, 32 kDa) (Kawaguchi and Hirano, 2002).
Negative_regulation (Reduction) of PKA Positive_regulation (facilitates) of Phosphorylation (dephosphorylation) of DARPP-32 associated with dopamine
1) Confidence 0.15 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.11 Pain Relevance 0.23

General Comments

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