INT276049

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pde1b, Rpa1) cytoplasm (Pde1b, Rpa1) signal transduction (Pde1b)
chromosome organization (Rpa1) DNA binding (Rpa1)
Pde1b (Mus musculus)
Rpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 20 69.92 Quite High
Kinase C 4 51.72 Quite High
gABA 44 32.56 Quite Low
depression 36 5.00 Very Low Very Low Very Low
long-term potentiation 16 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
interneuron 4 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 36 5.00 Very Low Very Low Very Low
Adhesions 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of the threshold for RP induction by PDE1
PDE1 Regulation (Regulation) of Positive_regulation (induction) of RP
1) Confidence 0.04 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.03
Thus, PDE1 is a critical regulator of the [Ca2+]i threshold for RP induction so that RP is not induced by a weak stimulation.


PDE1 Regulation (regulator) of Positive_regulation (induction) of RP
2) Confidence 0.02 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Verification of PDE1-mediated control of the [Ca2+]i threshold for RP induction
PDE1 Regulation (control) of Positive_regulation (induction) of RP
3) Confidence 0.02 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.03
Thus, the combined applications of computational simulation and cell biological experiments revealed a critical role of the feedforward inhibition of CaMKII by PDE1 in regulating the threshold for RP induction.
PDE1 Regulation (regulating) of Positive_regulation (induction) of RP
4) Confidence 0.02 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0

General Comments

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