INT276050

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Context Info
Confidence 0.15
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde1b) nucleus (Pde1b) cell cycle (Calm3)
cytoplasm (Pde1b)
Calm3 (Mus musculus)
Pde1b (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 33 61.64 Quite High
Central nervous system 6 44.56 Quite Low
long-term potentiation 12 20.24 Low Low
depression 27 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
interneuron 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 27 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The limited influence of calcineurin activity on the Ca2+ threshold for RP induction is presumably attributable to its shorter-lasting effect on PP-1 activity and the lower affinity for Ca2+/CaM compared with PDE1.
CaM Binding (affinity) of PDE1
1) Confidence 0.15 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Interestingly, the affinity of B-type of PDE1 (PDE1B) for Ca2+/CaM is reduced when it is phosphorylated by CaMKII (Hashimoto et al, 1989).
CaM Binding (affinity) of PDE1
2) Confidence 0.14 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
This sustained decrease of PDE1 activity was caused by CaMKII-mediated reduction of the affinity of PDE1 for Ca2+/CaM, as described below.
CaM Binding (affinity) of PDE1
3) Confidence 0.13 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.06

General Comments

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