INT276065

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Context Info
Confidence 0.56
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Camk2a, Pde1b) signal transduction (Pde1b) nucleus (Pde1b)
plasma membrane (Camk2a) kinase activity (Camk2a)
Camk2a (Mus musculus)
Pde1b (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 8 74.44 Quite High
Serotonin 8 72.52 Quite High
dopamine receptor 8 72.08 Quite High
Dopamine 8 61.44 Quite High
Pyramidal cell 8 61.20 Quite High
gABA 88 49.28 Quite Low
depression 72 47.88 Quite Low
agonist 8 40.44 Quite Low
long-term potentiation 32 29.48 Quite Low
GABAergic 8 24.16 Low Low
Disease Link Frequency Relevance Heat
Depression 72 47.88 Quite Low
Adhesions 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The other is downregulation of PDE1 by CaMKII through decreasing the affinity for Ca2+/CaM (Hashimoto et al, 1989), which would facilitate the PP-1 inhibition by phospho-DARPP-32 through augmentation of the PKA activity.
CaMKII Negative_regulation (downregulation) of PDE1
1) Confidence 0.56 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Our simulation reproduced the RP induction and its suppression in response to different combinations of inputs, and suggested the important role of cooperative actions of two positive-feedback loops, CaMKII autophosphorylation and CaMKII-mediated downregulation of phosphodiesterase 1 (PDE1), a type of Ca2+/CaM-dependent PDE.
CaMKII-mediated Negative_regulation (downregulation) of PDE1
2) Confidence 0.41 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.03
Thus, CaMKII-mediated inhibition of PDE1 might work as a positive-feedback loop (Figure 1A and C).
CaMKII-mediated Negative_regulation (inhibition) of PDE1
3) Confidence 0.41 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Thus, it is likely that CaMKII-mediated inhibition of PDE1 in turn supports the CaMKII activity.
CaMKII-mediated Negative_regulation (inhibition) of PDE1
4) Confidence 0.41 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Thus, PDE1 inhibition by CaMKII seemed to dynamically change signaling cascades from a dephosphorylation-dominant state to a phosphorylation-dominant state through alteration of the PP-1 activity.
CaMKII Negative_regulation (inhibition) of PDE1
5) Confidence 0.41 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Thus, CaMKII-mediated inhibition of PDE1 was incorporated into the model.
CaMKII-mediated Negative_regulation (inhibition) of PDE1
6) Confidence 0.41 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.14
Our model showed that synergistic action of two positive-feedback reactions, the CaMKII autophosphorylation at Thr286/287 and the negative regulation of PDE1 by CaMKII, is critical for the sustained CaMKII activation.
CaMKII Negative_regulation (regulation) of PDE1
7) Confidence 0.41 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
The sustained CaMKII activation depended on synergistic actions of two positive-feedback reactions, CaMKII autophosphorylation and CaMKII-mediated inhibition of a CaM-dependent phosphodiesterase, PDE1.
CaMKII-mediated Negative_regulation (inhibition) of PDE1
8) Confidence 0.18 Published 2009 Journal Mol Syst Biol Section Abstract Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0

General Comments

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