INT27607

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 3.22
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
spinal 1
macrophage 1
gastric epithelium 1
sympathetic 1
dorsal horn 1
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 11 100.00 Very High Very High Very High
Dorsal horn 1 99.30 Very High Very High Very High
Inflammation 17 99.04 Very High Very High Very High
Spinal cord 4 99.04 Very High Very High Very High
Antinociceptive 2 98.40 Very High Very High Very High
Paracetamol 14 98.30 Very High Very High Very High
Hyperalgesia 1 90.56 High High
allodynia 1 89.88 High High
Analgesic 6 84.68 Quite High
guanethidine 2 76.84 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 41 99.96 Very High Very High Very High
Peptic Ulcer 1 99.52 Very High Very High Very High
Adhesions 4 99.12 Very High Very High Very High
INFLAMMATION 19 99.04 Very High Very High Very High
Nociception 11 98.96 Very High Very High Very High
Hepatotoxicity 4 98.78 Very High Very High Very High
Cancer 78 98.36 Very High Very High Very High
Pancreatic Cancer 84 98.00 Very High Very High Very High
Hyperalgesia 1 90.56 High High
Neuropathic Pain 1 89.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The study suggested gaultherin did not cause gastric ulcer for the reason that it released salicylate in intestine slowly, not in stomach and it left the cyclooxygenase-1 unaffected, which was the source of cytoprotective prostaglandins in gastric epithelium.
Neg (not) Localization (released) of cyclooxygenase-1 in gastric epithelium associated with peptic ulcer
1) Confidence 0.59 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16375889 Disease Relevance 0.37 Pain Relevance 0.22
Since nitric oxide synthase inhibitors are antinociceptive by an effect in the spinal cord (dorsal horn) this would appear to be a likely location for the nitric oxide synthase and cyclooxygenase enzymes targetted by 7-nitro indazole and flurbiprofen respectively.
Spec (likely) Localization (location) of cyclooxygenase in dorsal horn associated with dorsal horn, antinociceptive and spinal cord
2) Confidence 0.47 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7535708 Disease Relevance 0.17 Pain Relevance 0.46
The macrophage plays a major role in the immune response and the inflammatory process, it has the capacity to synthesize and secrete arachidonic acid oxygenation products derived from both cyclooxygenase and lipoxygenase catalyzed pathways, and has been used extensively to study the effect of inhibitors of phospholipases, cyclooxygenase and lipoxygenase enzymes.
Localization (secrete) of cyclooxygenase in macrophage associated with inflammation
3) Confidence 0.31 Published 1989 Journal Medicina (B Aires) Section Abstract Doc Link 2640487 Disease Relevance 0.24 Pain Relevance 0.25
, IL-1 and IL-8, the nociceptive activity of which (in mice) seems to be due to the release of cyclooxygenase and sympathetic metabolites.



Localization (release) of cyclooxygenase in sympathetic associated with nociception
4) Confidence 0.23 Published 1997 Journal Mediators Inflamm Section Abstract Doc Link PMC2365829 Disease Relevance 0.82 Pain Relevance 0.36
In vitro, the pseudopterosins were inactive as inhibitors of phospholipase A2, cyclooxygenase, cytokine release, or as regulators of adhesion molecule expression.
Localization (release) of cyclooxygenase associated with adhesions and cytokine
5) Confidence 0.13 Published 1998 Journal Life Sci. Section Abstract Doc Link 9651113 Disease Relevance 0.25 Pain Relevance 0.24
Acetaminophen (APAP) elicits hepatotoxicity via multifactorial pathways, including increased apoptosis, cyclooxygenase (Cox-2) generation, reactive metabolite release, and glutathione (GSH) depletion.
Localization (release) of cyclooxygenase associated with paracetamol, hepatotoxicity and apoptosis
6) Confidence 0.12 Published 2008 Journal Dig. Dis. Sci. Section Abstract Doc Link 18373199 Disease Relevance 0.42 Pain Relevance 0.57
Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2 receptors.
Localization (localization) of cyclooxygenase in spinal associated with cytokine
7) Confidence 0.09 Published 2008 Journal J. Neurochem. Section Title Doc Link 18028337 Disease Relevance 0.33 Pain Relevance 0.45
Feasibility of targeting cyclooxygenase and lipoxygenase for treatment and prevention of pancreatic cancer
Localization (cyclooxygenase) of cyclooxygenase associated with pancreatic cancer
8) Confidence 0.02 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.62 Pain Relevance 0.06

General Comments

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