INT27608

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Context Info
Confidence 0.61
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.66
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
macrophage 2
Alox5 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 38 99.40 Very High Very High Very High
Inflammation 130 99.04 Very High Very High Very High
IPN 2 97.76 Very High Very High Very High
Hyperalgesia 1 96.24 Very High Very High Very High
antagonist 7 95.28 Very High Very High Very High
aspirin 13 85.84 High High
Analgesic 5 84.88 Quite High
Paracetamol 2 80.88 Quite High
diclofenac 4 77.36 Quite High
Pain 3 63.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 141 99.04 Very High Very High Very High
Pancreatic Cancer 84 98.68 Very High Very High Very High
Cancer 85 98.36 Very High Very High Very High
Inflammatory Pain 2 97.76 Very High Very High Very High
Pneumonia 3 97.70 Very High Very High Very High
Hyperalgesia 1 96.24 Very High Very High Very High
Hypotension 1 88.40 High High
Lung Cancer 9 83.44 Quite High
Leukemia 2 81.16 Quite High
Colon Cancer 6 79.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Table 1 shows primer sequences used to detect 5-LOX, DNMTs, and cyclophilin mRNAs (primers were purchased from Integrated DNA Technologies, Inc., Coralville, IA).
Localization (detect) of 5-LOX
1) Confidence 0.61 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.08 Pain Relevance 0.08
We found that the number of motifs which describe the colocalization of 5-lipoxygenase (5-LO) or 12-LO with other proteins increased disproportionally after dipyrone treatment.
Localization (colocalization) of 5-LO
2) Confidence 0.54 Published 2009 Journal J. Proteome Res. Section Abstract Doc Link 19697962 Disease Relevance 0.27 Pain Relevance 0.28
Chronic administration of butylated hydroxytoluene (BHT) to mice stimulates pulmonary inflammation characterized by vascular leakage and macrophage infiltration into the air spaces, increased PGE2 production, and translocation of 5-lipoxygenase (5-LO) from the cytosol to the particulate fraction.
Localization (translocation) of 5-LO in macrophage associated with inflammation and pneumonia
3) Confidence 0.53 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12376474 Disease Relevance 0.88 Pain Relevance 0.39
The macrophage plays a major role in the immune response and the inflammatory process, it has the capacity to synthesize and secrete arachidonic acid oxygenation products derived from both cyclooxygenase and lipoxygenase catalyzed pathways, and has been used extensively to study the effect of inhibitors of phospholipases, cyclooxygenase and lipoxygenase enzymes.
Localization (secrete) of lipoxygenase in macrophage associated with inflammation
4) Confidence 0.10 Published 1989 Journal Medicina (B Aires) Section Abstract Doc Link 2640487 Disease Relevance 0.25 Pain Relevance 0.26
Feasibility of targeting cyclooxygenase and lipoxygenase for treatment and prevention of pancreatic cancer
Localization (cyclooxygenase) of lipoxygenase associated with pancreatic cancer
5) Confidence 0.07 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.67 Pain Relevance 0.06
AA is metabolized by three major oxidative pathways: 1) cyclooxygenase (COX), forming prostaglandins and related eicosanoids; 2) lipoxygenase (LOX), forming leukotrienes and related compounds; and 3) CYP450, forming epoxides (2C/2J) and 20-HETEs (4A/4F).
Localization (metabolized) of lipoxygenase
6) Confidence 0.05 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.35 Pain Relevance 0.17
These authors concluded that the mechanism of action of these NSAIDs is not related to their COX, lipoxygenase, NF?
Localization (lipoxygenase) of lipoxygenase associated with cinod
7) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 0.16 Pain Relevance 0.44

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