INT2761

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Context Info
Confidence 0.61
First Reported 1976
Last Reported 2011
Negated 19
Speculated 9
Reported most in Abstract
Documents 119
Total Number 128
Disease Relevance 18.80
Pain Relevance 60.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
neurons 14
brain 5
neuronal 4
cortex 3
ventral 3
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 1786 100.00 Very High Very High Very High
GABAergic 545 100.00 Very High Very High Very High
antagonist 431 100.00 Very High Very High Very High
Dopamine 368 100.00 Very High Very High Very High
agonist 344 100.00 Very High Very High Very High
Neurotransmitter 271 100.00 Very High Very High Very High
Glutamate 236 100.00 Very High Very High Very High
Morphine 104 100.00 Very High Very High Very High
ketamine 97 100.00 Very High Very High Very High
GABA receptor 92 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 18 100.00 Very High Very High Very High
Pain 62 99.96 Very High Very High Very High
Generalized Anxiety Disorder 77 99.78 Very High Very High Very High
Convulsion 203 99.74 Very High Very High Very High
Drug Dependence 35 99.16 Very High Very High Very High
Anxiety Disorder 116 98.88 Very High Very High Very High
Stress 37 98.74 Very High Very High Very High
Spasticity 49 98.60 Very High Very High Very High
Headache 13 98.54 Very High Very High Very High
Cerebral Palsy 86 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The chemical structure and behavioral properties of gabapentin strongly suggest actions on inhibitory neurotransmission mediated by gamma-aminobutyric acid (GABA); however, gabapentin does not directly modulate GABAA or GABAB receptors.
Neg (not) Regulation (modulate) of GABAA associated with gaba and gabapentin
1) Confidence 0.61 Published 2006 Journal Anesthesiology Section Abstract Doc Link 16871066 Disease Relevance 0 Pain Relevance 0.61
The GABA receptors are regulated independently from acetylcholine (ACh) receptors on the neurons since the levels of ACh and GABA sensitivity are influenced differently by culture age and by chronic exposure to GABA or elevated K+ concentrations.
Neg (independently) Regulation (regulated) of GABA in neurons associated with gaba and gaba receptor
2) Confidence 0.61 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 2995607 Disease Relevance 0.40 Pain Relevance 0.48
We did not find any alterations in GABA(B)-receptor function after chronic nicotine treatment.
Neg (not) Regulation (alterations) of GABA associated with gaba and nicotine
3) Confidence 0.60 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18786163 Disease Relevance 0 Pain Relevance 1.55
While ethanol has diverse effects in the brain, ethanol has been shown to increase the firing rates of mesolimbic dopamine neurons by modulating GABAA receptors located on GABAergic neurons in the VTA (71).
Regulation (modulating) of GABAA in GABAergic neurons associated with ventral tegmentum, dopamine and gabaergic
4) Confidence 0.60 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529396 Disease Relevance 0.36 Pain Relevance 1.02
Mouse cerebellar granule cell differentiation: electrical activity regulates the GABAA receptor alpha 6 subunit gene.
Regulation (regulates) of GABAA in cerebellar granule cell
5) Confidence 0.60 Published 1998 Journal J. Neurosci. Section Title Doc Link 9525999 Disease Relevance 0 Pain Relevance 0.03
In these conditions the effect of isoflurane which mainly affect GABAA receptors [66]–[68] might not be apparent.
Regulation (affect) of GABAA associated with isoflurane
6) Confidence 0.60 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0.13 Pain Relevance 0.69
In some neurons, steroid metabolites known as neurosteroids modulate the function of the GABAA receptor.
Regulation (modulate) of GABAA in neurons
7) Confidence 0.58 Published 2003 Journal Endocrinology Section Abstract Doc Link 12960018 Disease Relevance 0 Pain Relevance 0.27
Celecoxib does not induce convulsions nor does it affect GABAA receptor binding activity in the presence of new quinolones in mice.
Neg (nor) Regulation (affect) of GABAA receptor associated with convulsion
8) Confidence 0.55 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 15659296 Disease Relevance 0.51 Pain Relevance 0.23
The effect of GABA (gamma-aminobutyric acid system) receptor agonists and antagonists on naloxone-induced jumping in morphine-dependent mice was examined.
Regulation (effect) of GABA associated with gaba, antagonist, narcan, agonist and morphine
9) Confidence 0.46 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10554880 Disease Relevance 0 Pain Relevance 0.80
To assess effects of chronic opiates on the major site of postsynaptic GABAergic activity, the GABAA receptor, we administered chronic morphine and naltrexone to mice and evaluated binding at the benzodiazepine and t-butylbicyclophosphorothionate (TBPS) sites and GABA-dependent chloride uptake.
Regulation (effects) of GABAA receptor associated with gaba, gabaergic, opiate and morphine
10) Confidence 0.45 Published 1990 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1697078 Disease Relevance 0 Pain Relevance 0.65
-TH PROG), are able to influence the synthesis of myelin proteins under the control of classical receptors (PR, progesterone receptor) and non classical receptors (GABA-A).
Regulation (control) of GABA-A associated with gaba
11) Confidence 0.44 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2873263 Disease Relevance 0.39 Pain Relevance 0.24
Neuroactive steroids have been postulated to cause anesthesia by binding to unique steroid recognition sites on gamma-aminobutyric acid (GABA) receptors and modulating GABA receptor function.
Regulation (modulating) of GABA associated with gaba, anesthesia and gaba receptor
12) Confidence 0.42 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8967980 Disease Relevance 0 Pain Relevance 0.44
This study investigated the effects of a gamma-amino-butyric acid type A (GABAA) receptor agonist and antagonist on morphine-induced locomotor sensitization in male albino mice.
Regulation (effects) of GABAA associated with antagonist, agonist and morphine
13) Confidence 0.42 Published 2007 Journal Behav Pharmacol Section Abstract Doc Link 17551323 Disease Relevance 0 Pain Relevance 0.63
In 2007, Chattopadhyaya et al. demonstrated in organotypic cortical slices that endogenous GABA levels regulate cortical basket-cell axonal branching through the activation of GABAA, and to lesser extent GABAB receptors during the maturation of inhibitory circuits (Chattopadhyaya et al., 2007).
Regulation (regulate) of GABA associated with gaba
14) Confidence 0.38 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0 Pain Relevance 0.48
The GABAA receptor antagonist bicuculline did not influence the pattern of activity distribution.
Neg (not) Regulation (influence) of GABAA receptor associated with antagonist
15) Confidence 0.38 Published 1996 Journal Exp Brain Res Section Abstract Doc Link 9007547 Disease Relevance 0 Pain Relevance 0.18
Chronic treatment with diazepam has been shown to alter GABAA receptor affinity for the agonist GABA and some BDZ binding characteristics (Tietz et al 1989; Wu et al 1994).
Regulation (alter) of GABA associated with gaba and agonist
16) Confidence 0.38 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526378 Disease Relevance 0.27 Pain Relevance 0.24
The differential effects on PTZ-induced seizures produced after subchronic diazepam, vigabatrin, and gabapentin may result from changes in specific subunits that regulate the GABAA or BDZ binding.
Regulation (regulate) of GABAA associated with convulsion and gabapentin
17) Confidence 0.38 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526378 Disease Relevance 0.17 Pain Relevance 0.56
Robust changes in neurosteroid levels, such as those that occur following stress, over the ovarian cycle, and throughout pregnancy, profoundly alter GABAA receptor (GABAAR) structure and function and underlie the associated changes in neuronal excitability.
Regulation (alter) of GABAA receptor in neuronal associated with stress and neuronal excitability
18) Confidence 0.38 Published 2009 Journal Psychoneuroendocrinology Section Abstract Doc Link 19632051 Disease Relevance 0.58 Pain Relevance 0.30
Topiramate is a pharmacologically rich neuroactive drug that has been demonstrated to possess many molecular activities, such as inhibition of voltage-gated sodium channels, modulation of voltage-gated potassium and calcium channels, modulation of GABAA and glutamate receptors, and carbonic anhydrase inhibition (Bialer et al. 2004; White, 2005).
Regulation (modulation) of GABAA associated with glutamate receptor, calcium channel and sodium channel
19) Confidence 0.36 Published 2008 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2746576 Disease Relevance 0.24 Pain Relevance 0.76
These effects were blocked by the GABAA antagonist bicuculline, implying a role for GABAA receptors.
Regulation (role) of GABAA associated with antagonist
20) Confidence 0.36 Published 2004 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC416489 Disease Relevance 0.15 Pain Relevance 0.44

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