INT276129

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MCAT)
Anatomy Link Frequency
striatum 2
MCAT (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 1 29.76 Quite Low
Substantia nigra 1 28.96 Quite Low
Dopamine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
monoamine 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Root ganglion neuron 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 110 97.98 Very High Very High Very High
Parkinson's Disease 5 32.84 Quite Low
Death 2 28.64 Quite Low
Neurodegenerative Disease 1 24.12 Low Low
Stroke 3 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low
Optic Disorders 2 5.00 Very Low Very Low Very Low
Neurological Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Movement, fission, and fusion of mitochondria are functions that are also essential for neuronal survival. [8] Studies at the ultrastructural level in human PD caudate and striatum detected a disruption in the distribution of both microtubules and organelles such as mitochondria. [9] Neurotoxins that are used to model PD pathogenesis (1-methyl-4-phenylpyridinium (MPP+) and rotenone) compromise mitochondrial function by inhibiting complex I of the mtETC.
Negative_regulation (inhibiting) of mtETC Binding (complex) of in striatum associated with disease
1) Confidence 0.01 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2711937 Disease Relevance 0.49 Pain Relevance 0

General Comments

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