INT276171

Context Info Confidence 0.52 First Reported 2009 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 3 Total Number 6 Disease Relevance 7.24 Pain Relevance 1.64

mitochondrion (Pten) aging (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency blood 4 myocardium 2 cardiomyocyte 2 Pten (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 180 99.90 fibrosis 42 90.72 Inflammation 9 83.56 anesthesia 9 5.00 imagery 6 5.00 cytokine 3 5.00 ketamine 3 5.00 Perioperative pain 3 5.00 ischemia 3 5.00 Buprenorphine 3 5.00

Disease Link Frequency Relevance Heat Myocardial Infarction 234 99.98 Aging 114 99.52 Diabetes Mellitus 165 98.64 Hyperglycemia 18 94.84 Stress 24 94.44 Apoptosis 150 94.20 Fibrosis 36 90.72 Hypertrophy 45 89.40 INFLAMMATION 9 83.56 Obesity 9 82.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is possible that the normalization of blood glucose by acetaminophen may contribute to the increased PTEN expression.

Spec (may) Positive_regulation (contribute) of Gene_expression (expression) of PTEN in blood associated with paracetamol

1) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.70 Pain Relevance 0.48

This increase in PTEN protein appeared to parallel decreases in the amount of Akt-Thr308 phosphorylation which support the notion that a loss of PTEN protein with aging may contribute to the hyper-phosphorylation of Akt, and that acetaminophen intervention may function in reducing Akt phosphorylation by increasing PTEN levels.

Positive_regulation (increasing) of Gene_expression (levels) of PTEN associated with paracetamol and aging

2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.51 Pain Relevance 0.40

It is possible that the normalization of blood glucose by acetaminophen may contribute to the increased PTEN expression.

Positive_regulation (increased) of Gene_expression (expression) of PTEN in blood associated with paracetamol

3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.70 Pain Relevance 0.48

In GK rats, MI induced an increase in PTEN protein expression, reduced Akt phosphorylation and a concomitant decrease in FOXO3a phosphorylation which might have contributed to the increase in cardiomyocyte apoptosis seen here.

Positive_regulation (increase) of Gene_expression (expression) of PTEN protein in cardiomyocyte associated with apoptosis and myocardial infarction

4) Confidence 0.12 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.42 Pain Relevance 0.13

Our results showed that MI increased myocardial PTEN protein expression in GK but not in Wistar rats (Figure 5A).

Positive_regulation (increased) of Gene_expression (expression) of PTEN protein associated with myocardial infarction

5) Confidence 0.12 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.05 Pain Relevance 0.03

In the GK rat myocardium, Akt- and FOXO3a-phosphorylation was decreased and nuclear localization of FOXO3a was increased concomitantly with increased PTEN protein expression.

Positive_regulation (increased) of Gene_expression (expression) of PTEN protein in myocardium

6) Confidence 0.08 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.86 Pain Relevance 0.12

General Comments

This test has worked.