INT276177

Context Info Confidence 0.34 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.51 Pain Relevance 0.84

mitochondrion (Pten) aging (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Pten (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 120 92.68 cytokine 2 5.00

Disease Link Frequency Relevance Heat Aging 76 99.32 Hyperglycemia 8 93.40 Apoptosis 20 78.96 Frailty 10 77.84 Obesity 4 77.48 Muscle Disease 2 23.04 Body Weight 8 5.00 Death 4 5.00 Hypoxia 2 5.00 Insulin Resistance 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is thought that high glucose levels can result in decreased PTEN expression and decreases in PTEN phosphatase activity [14].

Regulation (result) of Gene_expression (expression) of PTEN

1) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.57 Pain Relevance 0.47

Whether changes in PTEN expression alone or if the presence of other factors is required to explain the effects of aging on Akt expression and phosphorylation will require further investigation.

Regulation (changes) of Gene_expression (expression) of PTEN associated with aging

2) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.94 Pain Relevance 0.37

General Comments

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