INT276179

Context Info Confidence 0.46 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.81 Pain Relevance 0.63

mitochondrion (Pten) aging (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency muscle 1 adipocytes 1 Pten (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 120 97.48 cytokine 2 5.00

Disease Link Frequency Relevance Heat Aging 76 99.52 Obesity 4 93.88 Frailty 10 93.16 Apoptosis 20 88.52 Tuberous Sclerosis 2 55.28 Hyperglycemia 8 31.04 Body Weight 8 5.00 Death 4 5.00 Hypoxia 2 5.00 Insulin Resistance 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results are consistent with the alterations in PTEN protein levels and suggest that PTEN may regulate the phosphorylation of Akt Thr308 in skeletal muscle using a mechanism similar to that previously observed in adipocytes [13].

Regulation (alterations) of PTEN protein in adipocytes associated with obesity

1) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.31 Pain Relevance 0.40

Further, we demonstrate that acetaminophen administration functions to prevent age-associated Akt hyper-phosphorylation and dysfunction in aging muscle by decreasing S-nitrosylated Akt and restoring PTEN protein levels.

Regulation (nitrosylated) of PTEN protein in muscle associated with paracetamol and aging

2) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.50 Pain Relevance 0.22

General Comments

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