INT276180

Context Info Confidence 0.35 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.89 Pain Relevance 0.43

mitochondrion (Pten) aging (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency muscle 2 Pten (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 60 93.40 cytokine 1 5.00

Disease Link Frequency Relevance Heat Hyperglycemia 4 99.32 Aging 38 98.82 Apoptosis 10 68.96 Frailty 5 67.84 Obesity 2 48.32 Muscle Disease 1 13.04 Body Weight 4 5.00 Death 2 5.00 Hypoxia 1 5.00 Insulin Resistance 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, aging-associated hyperglycemia and decreases in pPTEN level may result in decreased PTEN protein levels, which could act to increase the phosphorylation of Akt at Thr308 in aging muscle.

Spec (may) Positive_regulation (result) of Negative_regulation (decreased) of PTEN protein in muscle associated with hyperglycemia and aging

1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.89 Pain Relevance 0.43

General Comments

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