INT276181

Context Info Confidence 0.44 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 2.48 Pain Relevance 1.37

mitochondrion (Pten) aging (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency body 2 Pten (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 240 94.52 cytokine 4 30.76

Disease Link Frequency Relevance Heat Hyperglycemia 16 97.80 Hepatotoxicity 4 96.88 Aging 152 96.08 Body Weight 16 95.72 Apoptosis 40 83.28 Frailty 20 82.16 Obesity 8 77.08 Hypertrophy 4 37.20 Death 8 5.00 Hypoxia 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is thought that high glucose levels can result in decreased PTEN expression and decreases in PTEN phosphatase activity [14].

Negative_regulation (decreased) of Gene_expression (expression) of PTEN

1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.57 Pain Relevance 0.47

On the basis of previous work demonstrating that chronic acetaminophen (N-acetyl p-aminophenol, APAP) intake (30 mg/kg body weight/day) can be safely (e.g. in the absence of hepatotoxicity) used to prevent age-associated hyperglycemia [23], and other findings suggesting that elevated glucose levels can induce iNOS expression [19], [20] while reduce PTEN expression [14], we tested if this type of treatment regimen would also be effective in improving Akt function.

Negative_regulation (reduce) of Gene_expression (expression) of PTEN in body associated with hyperglycemia, paracetamol, body weight and hepatotoxicity

2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.99 Pain Relevance 0.22

It is thought that high glucose levels can result in decreased PTEN expression and decreases in PTEN phosphatase activity [14].

Negative_regulation (decreased) of Gene_expression (expression) of PTEN

3) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.57 Pain Relevance 0.47

Paradoxically, these increases in Akt phosphorylation were associated with diminished mammalian target of rapamycin (mTOR) phosphorylation, along with decreased levels of insulin receptor beta (IR-?)

Negative_regulation (decreased) of Gene_expression (levels) of PTEN

4) Confidence 0.28 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2712760 Disease Relevance 0.35 Pain Relevance 0.22

General Comments

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