INT276188

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.75
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Foxo1) nucleus (Foxo1) DNA binding (Foxo1)
cytoplasm (Foxo1)
Anatomy Link Frequency
muscle 2
Foxo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 10 91.88 High High
addiction 2 73.96 Quite High
Paracetamol 120 72.52 Quite High
Hippocampus 2 18.88 Low Low
Central nervous system 2 11.56 Low Low
ischemia 8 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tuberous Sclerosis 2 100.00 Very High Very High Very High
Aids-related Complex 44 95.92 Very High Very High Very High
Appetite Loss 10 93.20 High High
Body Weight 42 88.88 High High
Aging 83 84.72 Quite High
Obesity 15 73.60 Quite High
Frailty 10 70.72 Quite High
Apoptosis 28 66.08 Quite High
Heart Disease 2 65.44 Quite High
Coronary Artery Disease 4 63.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blocking hypothalamic Sirt1 activity (Figure S4B) reversed the decrease in FoxO1 acetylation, suggesting that fasting induced deacetylation of FoxO1 required Sirt1 (Figure 4B).
Negative_regulation (decrease) of FoxO1
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.18 Pain Relevance 0
SirT1 regulates several transcription factors including FoxO1, which is inactivated by phosphorylation via Akt [32].
Negative_regulation (inactivated) of FoxO1
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009730 Disease Relevance 0.27 Pain Relevance 0
Inhibition of hypothalamic Sirt1 activity reversed the fasting induced decrease of FoxO1 acetylation, and resulted in increased POMC and decreased AgRP expressions.
Negative_regulation (decrease) of FoxO1
3) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.45 Pain Relevance 0.08
Interestingly, these data do not appear to predict down-stream Akt signaling since the phosphorylation level of mTOR (Ser2448) [9] (Figure 2A), tuberous sclerosis complex-2 (TSC2) and forkhead box O1 (FoxO1) (data not shown) was lower in the very aged muscle.
Negative_regulation (level) of forkhead box O1 in muscle associated with tuberous sclerosis
4) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.43 Pain Relevance 0.07
Interestingly, these data do not appear to predict down-stream Akt signaling since the phosphorylation level of mTOR (Ser2448) [9] (Figure 2A), tuberous sclerosis complex-2 (TSC2) and forkhead box O1 (FoxO1) (data not shown) was lower in the very aged muscle.
Negative_regulation (level) of FoxO1 in muscle associated with tuberous sclerosis
5) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.43 Pain Relevance 0.07

General Comments

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