INT276189

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.20
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 60 100.00 Very High Very High Very High
ischemia 10 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 38 86.16 High High
Hyperglycemia 4 60.52 Quite High
Insulin Resistance 1 36.60 Quite Low
Obesity 2 36.24 Quite Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Hypoxia 7 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 6 5.00 Very Low Very Low Very Low
Brain Injury 6 5.00 Very Low Very Low Very Low
Frailty 5 5.00 Very Low Very Low Very Low
Brain Hemorrhage 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike that observed for iNOS, acetaminophen did not appear to affect the regulation of nNOS or eNOS expression (Figure 5B) suggesting perhaps that the normalization of Akt S-nitrosylation by acetaminophen may be dependent on the reduced expression of iNOS.
Spec (may) Regulation (dependent) of Localization (normalization) of Akt associated with paracetamol
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.20 Pain Relevance 0.50
Moreover, the downstream signaling molecule of Akt, GSK3?
Regulation (Moreover) of Localization (molecule) of Akt
2) Confidence 0.36 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
Moreover, the downstream signaling molecule of Akt, GSK3?
Regulation (signaling) of Localization (molecule) of Akt
3) Confidence 0.36 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0

General Comments

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