INT276196

Context Info Confidence 0.38 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.19 Pain Relevance 1.41

mitochondrion (Pten) aging (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Pten (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 180 99.78 cytokine 3 5.00

Disease Link Frequency Relevance Heat Aging 114 64.48 Apoptosis 30 5.00 Frailty 15 5.00 Body Weight 12 5.00 Hyperglycemia 12 5.00 Death 6 5.00 Obesity 6 5.00 Hypoxia 3 5.00 Insulin Resistance 3 5.00 Hypertrophy 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Chronic acetaminophen treatment increased the amount of phosphorylated PTEN (pPTEN) (Ser380/Thr382/Thr383) and PTEN protein by 23.9% and 39.9%, respectively, when compared to that in the age-matched control (P<0.05).

Positive_regulation (increased) of Phosphorylation (phosphorylated) of pPTEN associated with paracetamol

1) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.06 Pain Relevance 0.47

Chronic acetaminophen treatment increased the amount of phosphorylated PTEN (pPTEN) (Ser380/Thr382/Thr383) and PTEN protein by 23.9% and 39.9%, respectively, when compared to that in the age-matched control (P<0.05).

Positive_regulation (increased) of Phosphorylation (phosphorylated) of PTEN protein associated with paracetamol

2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.06 Pain Relevance 0.47

Chronic acetaminophen treatment increased the amount of phosphorylated PTEN (pPTEN) (Ser380/Thr382/Thr383) and PTEN protein by 23.9% and 39.9%, respectively, when compared to that in the age-matched control (P<0.05).

Positive_regulation (increased) of Phosphorylation (phosphorylated) of PTEN associated with paracetamol

3) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.06 Pain Relevance 0.47

General Comments

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