INT276198

Context Info Confidence 0.52 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 10 Disease Relevance 5.02 Pain Relevance 3.88

mitochondrion (Pten) aging (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency muscle 1 Pten (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 600 99.78 cytokine 10 5.00

Disease Link Frequency Relevance Heat Aging 380 99.32 Hyperglycemia 40 99.32 Obesity 20 97.56 Frailty 50 83.04 Apoptosis 100 82.56 Muscle Disease 10 81.84 Body Weight 40 5.00 Death 20 5.00 Hypoxia 10 5.00 Insulin Resistance 10 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This increase in PTEN protein appeared to parallel decreases in the amount of Akt-Thr308 phosphorylation which support the notion that a loss of PTEN protein with aging may contribute to the hyper-phosphorylation of Akt, and that acetaminophen intervention may function in reducing Akt phosphorylation by increasing PTEN levels.

Positive_regulation (increase) of PTEN protein associated with paracetamol and aging

1) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.51 Pain Relevance 0.33

Chronic acetaminophen treatment increased the amount of phosphorylated PTEN (pPTEN) (Ser380/Thr382/Thr383) and PTEN protein by 23.9% and 39.9%, respectively, when compared to that in the age-matched control (P<0.05).

Positive_regulation (increased) of PTEN associated with paracetamol

2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.06 Pain Relevance 0.47

Chronic acetaminophen treatment increased the amount of phosphorylated PTEN (pPTEN) (Ser380/Thr382/Thr383) and PTEN protein by 23.9% and 39.9%, respectively, when compared to that in the age-matched control (P<0.05).

Positive_regulation (increased) of pPTEN associated with paracetamol

3) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.06 Pain Relevance 0.47

Chronic acetaminophen treatment increased the amount of phosphorylated PTEN (pPTEN) (Ser380/Thr382/Thr383) and PTEN protein by 23.9% and 39.9%, respectively, when compared to that in the age-matched control (P<0.05).

Positive_regulation (increased) of PTEN protein associated with paracetamol

4) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.06 Pain Relevance 0.47

The data of the present study show that a loss of PTEN protein in aging may contribute to the increased phosphorylation of Akt, and that acetaminophen intervention can restore both PTEN and pPTEN levels.

Positive_regulation (restore) of PTEN associated with paracetamol and aging

5) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.76 Pain Relevance 0.33

The data of the present study show that a loss of PTEN protein in aging may contribute to the increased phosphorylation of Akt, and that acetaminophen intervention can restore both PTEN and pPTEN levels.

Positive_regulation (restore) of pPTEN associated with paracetamol and aging

6) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.76 Pain Relevance 0.33

This increase in PTEN protein appeared to parallel decreases in the amount of Akt-Thr308 phosphorylation which support the notion that a loss of PTEN protein with aging may contribute to the hyper-phosphorylation of Akt, and that acetaminophen intervention may function in reducing Akt phosphorylation by increasing PTEN levels.

Positive_regulation (increasing) of PTEN associated with paracetamol and aging

7) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.51 Pain Relevance 0.40

Therefore, aging-associated hyperglycemia and decreases in pPTEN level may result in decreased PTEN protein levels, which could act to increase the phosphorylation of Akt at Thr308 in aging muscle.

Spec (may) Positive_regulation (result) of PTEN protein in muscle associated with hyperglycemia and aging

8) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.89 Pain Relevance 0.43

Interestingly, 6 months of acetaminophen intervention restored PTEN protein levels similar to that found in 6- and 27-month rats.

Positive_regulation (restored) of PTEN protein associated with paracetamol

9) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.49 Pain Relevance 0.26

Our data also show that pPTEN levels were decreased with aging and that acetaminophen treatment restored pPTEN comparable to that observed in 6- and 27-month rats (Figure 6).

Positive_regulation (restored) of pPTEN associated with paracetamol and aging

10) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.90 Pain Relevance 0.40

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