INT276199

Context Info Confidence 0.30 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.40 Pain Relevance 0.67

mitochondrion (Pten) aging (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Pten (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 60 96.96 amygdala 5 88.36 Hippocampus 2 87.84 Pyramidal cell 1 78.72 Somatosensory cortex 1 76.76 Serotonin 11 50.00 cocaine 39 37.88 Dopamine 6 32.92 Eae 18 19.52 Cannabinoid receptor 3 17.12

Disease Link Frequency Relevance Heat Macrocephaly 1 99.80 Aging 38 75.16 Anxiety Disorder 23 61.52 Adhesions 2 56.88 Apoptosis 13 51.84 Targeted Disruption 6 50.00 Sprains And Strains 13 49.44 Increased Venous Pressure Under Development 2 13.96 Headache 2 10.36 Obesity 32 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Of interest, a recent study found an epistatic interaction of Slc6a4 and Pten for macrocephaly in mice [39].

Pten Binding (interaction) of associated with macrocephaly

1) Confidence 0.30 Published 2010 Journal BMC Genet Section Body Doc Link PMC2874760 Disease Relevance 0.32 Pain Relevance 0.21

Akt hyper-phosphorylation is associated with a loss of PTEN protein

PTEN protein Binding (associated) of

2) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.08 Pain Relevance 0.46

General Comments

This test has worked.