INT276201

Context Info Confidence 0.61 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 5 Disease Relevance 1.31 Pain Relevance 2.08

mitochondrion (Pten) aging (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency tail 1 Pten (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 300 99.30 cytokine 5 5.00

Disease Link Frequency Relevance Heat Hyperglycemia 20 91.72 Aging 190 90.72 Apoptosis 50 70.64 Obesity 10 63.24 Body Weight 20 55.52 Frailty 25 39.12 Death 10 5.00 Hypoxia 5 5.00 Insulin Resistance 5 5.00 Hypertrophy 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Chronic acetaminophen treatment increased the amount of phosphorylated PTEN (pPTEN) (Ser380/Thr382/Thr383) and PTEN protein by 23.9% and 39.9%, respectively, when compared to that in the age-matched control (P<0.05).

Phosphorylation (phosphorylated) of pPTEN associated with paracetamol

1) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.06 Pain Relevance 0.46

Chronic acetaminophen treatment increased the amount of phosphorylated PTEN (pPTEN) (Ser380/Thr382/Thr383) and PTEN protein by 23.9% and 39.9%, respectively, when compared to that in the age-matched control (P<0.05).

Phosphorylation (phosphorylated) of PTEN associated with paracetamol

2) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.06 Pain Relevance 0.46

Chronic acetaminophen treatment increased the amount of phosphorylated PTEN (pPTEN) (Ser380/Thr382/Thr383) and PTEN protein by 23.9% and 39.9%, respectively, when compared to that in the age-matched control (P<0.05).

Phosphorylation (phosphorylated) of PTEN protein associated with paracetamol

3) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.06 Pain Relevance 0.47

, phosphoinositide 3-kinase (PI3K), phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and phosphorylation of phosphoinositide-dependent kinase-1 (PDK1) (Ser241).

Phosphorylation (phosphorylation) of PTEN

4) Confidence 0.54 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2712760 Disease Relevance 0.35 Pain Relevance 0.21

It has also been documented that phosphorylation of the C-terminal tail of PTEN decreases the degradation of PTEN protein by increasing its stability [29].

Phosphorylation (phosphorylation) of PTEN in tail

5) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.77 Pain Relevance 0.47

General Comments

This test has worked.