INT276209

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nos2, Nfkb1) cytosol (Nos2, Nfkb1) signal transduction (Nos2, Nfkb1)
nucleus (Nos2, Nfkb1) mitochondrion (Nfkb1) aging (Nos2)
Anatomy Link Frequency
muscle 2
Nos2 (Rattus norvegicus)
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 60 98.42 Very High Very High Very High
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 4 94.98 High High
Aging 38 81.08 Quite High
Insulin Resistance 1 66.04 Quite High
Apoptosis 10 30.36 Quite Low
Frailty 5 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low
Hypertrophy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A previous study by our laboratory demonstrated that age-associated hyperglycemia and decreases in muscle glucose transporter-4 (Glut4) can be reversed by acetaminophen intervention [23], while other work using cultured cell has shown that acetaminophen can directly inhibit NO production and iNOS expression through its ability to diminish NF-kappaB binding to the iNOS gene promoter [28].
Negative_regulation (diminish) of iNOS Binding (binding) of NF-kappaB in muscle associated with hyperglycemia and paracetamol
1) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.31 Pain Relevance 0.34

General Comments

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