INT276213

Context Info Confidence 0.51 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.61 Pain Relevance 0.72

aging (Pten, Akt1) enzyme binding (Pten, Akt1) cytoplasm (Pten, Akt1) nucleus (Pten, Akt1) plasma membrane (Pten, Akt1) nucleoplasm (Akt1)

Anatomy Link Frequency adipocytes 4 Pten (Rattus norvegicus) Akt1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 120 93.32 cytokine 2 5.00

Disease Link Frequency Relevance Heat Obesity 4 99.84 Aging 76 78.20 Hyperglycemia 8 36.56 Apoptosis 20 5.00 Frailty 10 5.00 Body Weight 8 5.00 Death 4 5.00 Hypoxia 2 5.00 Insulin Resistance 2 5.00 Hypertrophy 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results are consistent with the alterations in PTEN protein levels and suggest that PTEN may regulate the phosphorylation of Akt Thr308 in skeletal muscle using a mechanism similar to that previously observed in adipocytes [13].

PTEN Spec (may) Regulation (regulate) of Phosphorylation (phosphorylation) of Akt in adipocytes associated with obesity

1) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.37 Pain Relevance 0.36

It has been reported that the phosphorylation of Thr308 of Akt, but not Ser473, is regulated by PTEN in adipocytes [13].

PTEN Regulation (regulated) of Phosphorylation (phosphorylation) of Akt in adipocytes associated with obesity

2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.24 Pain Relevance 0.36

General Comments

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