INT276216

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.61
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Akt1, Ins1) cytoplasm (Akt1, Ins1) nucleoplasm (Akt1)
transport (Akt1) aging (Akt1) enzyme binding (Akt1)
Anatomy Link Frequency
muscle fiber 1
Akt1 (Rattus norvegicus)
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 2 94.04 High High
Paracetamol 60 85.28 High High
fibrosis 28 13.76 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Perioperative pain 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 90 98.92 Very High Very High Very High
Aging 38 98.08 Very High Very High Very High
Frailty 5 94.20 High High
Cv Unclassified Under Development 2 94.04 High High
Diabetes Mellitus 110 90.24 High High
Stress 16 87.76 High High
Left Ventricular Hypertrophy 2 82.84 Quite High
Coronary Heart Disease 20 75.84 Quite High
Hypertrophy 29 72.08 Quite High
Myocardial Infarction 156 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A previous study revealed that essential components of the insulin signaling pathway upstream of the Akt kinase, such as insulin receptor ?
Akt kinase Binding (receptor) of insulin
1) Confidence 0.03 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.07 Pain Relevance 0.05
A previous study revealed that essential components of the insulin signaling pathway upstream of the Akt kinase, such as insulin receptor ?
Akt kinase Binding (receptor) of insulin
2) Confidence 0.03 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.07 Pain Relevance 0.05
Paradoxically, this increased Akt phosphorylation is associated with lower Akt kinase activity, diminished response to insulin, higher levels of myocyte apoptosis, lower abundance of contractile proteins myosin and actin, and a smaller muscle fiber cross-sectional area (atrophy).
Akt Binding (associated) of insulin in muscle fiber associated with frailty and apoptosis
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.46 Pain Relevance 0.31

General Comments

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