INT276250

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.70
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (RNH1)
Anatomy Link Frequency
thyroid 1
thyroid gland 1
RNH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 141 99.08 Very High Very High Very High
positron emission tomography 21 32.92 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
beta blocker 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperthyroidism 144 100.00 Very High Very High Very High
Goiter 9 95.12 Very High Very High Very High
Thyroid Disease 57 55.60 Quite High
Thyroid Neoplasm 99 50.00 Quite Low
Disease 66 16.04 Low Low
Cancer 36 15.20 Low Low
Metastasis 42 5.00 Very Low Very Low Very Low
Recurrence 15 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 12 5.00 Very Low Very Low Very Low
Autoimmune Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the whole, we think that the expected degree of final TV reduction after rhTSH plus RAI is in any case greater than that observed in long-term follow-up studies after RAI alone [3-5].
Negative_regulation (reduction) of RAI
1) Confidence 0.24 Published 2009 Journal Thyroid Res Section Body Doc Link PMC2713215 Disease Relevance 0.12 Pain Relevance 0
However, they found that the reduction in the volume of the goiter after rhTSH and RAI was unrelated to the thyroid dose retained, an observation in line with other studies conducted on patients with smaller goiters [17].
Negative_regulation (reduction) of RAI in thyroid associated with goiter and hyperthyroidism
2) Confidence 0.18 Published 2009 Journal Thyroid Res Section Body Doc Link PMC2713215 Disease Relevance 0.35 Pain Relevance 0
In a follow-up study lasting up to 12 months, Paz-Filho et al. [24] reported an average 50% reduction in TV after RAI (1110 MBq) in patients with an initial TV of 100 ml pre-treated with rhTSH (0.1 or 0.2 mg); most (about 70%) of this reduction occurred in the 1st year after treatment.
Negative_regulation (reduction) of RAI
3) Confidence 0.16 Published 2009 Journal Thyroid Res Section Body Doc Link PMC2713215 Disease Relevance 0.23 Pain Relevance 0
Thirty patients were randomized to the hypothyroid group and had levothyroxine replacement withheld, and after 4 to 6 weeks when the TSH was least 25 mU/L, they then received the ablative RAI dose.
Negative_regulation (received) of RAI
4) Confidence 0.10 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0 Pain Relevance 0.10
Patients randomized to THW discontinued levothyroxine for 5 weeks, then received the RAI dose.
Negative_regulation (received) of RAI associated with withdrawal
5) Confidence 0.10 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0 Pain Relevance 0.27
The studies summarized above generally used a standard schedule of administering rhTSH on days 1 and 2, then giving the ablative RAI on day 3 when TSH levels are at their peak, which should be optimal for RAI uptake into the thyroid gland.
Negative_regulation (giving) of RAI in thyroid gland
6) Confidence 0.10 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994210 Disease Relevance 0 Pain Relevance 0

General Comments

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