INT27628

Context Info Confidence 0.75 First Reported 1987 Last Reported 2010 Negated 0 Speculated 2 Reported most in Abstract Documents 28 Total Number 30 Disease Relevance 20.95 Pain Relevance 6.16

signal transduction (IL2RG) plasma membrane (IL2RG)

Anatomy Link Frequency PBMC 4 lymphocytes 2 bowel 2 femur 2 natural killer cell 1 IL2RG (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 65 100.00 Crohn's disease 40 99.50 anesthesia 14 99.48 Inflammation 36 99.00 spinal inflammation 8 98.24 Pain 10 97.84 abdominal pain 12 97.32 rheumatoid arthritis 10 97.08 palliative 3 95.04 bradykinin 66 89.00

Disease Link Frequency Relevance Heat Lymphatic System Cancer 51 99.86 Disease 120 99.68 Inflammatory Bowel Disease 30 99.68 Crystal Associated Disease 3 99.68 Necrosis 4 99.62 Diphtheria 9 99.50 Cancer 32 99.44 INFLAMMATION 33 99.00 Adhesions 1 98.92 Chronic Hepatitis 46 98.80

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression of IL-2Ralpha, IL-2Rbeta, and IL-2Rgamma in the pathological section was determined, respectively, by immunohistochemistry (IHC) and in situ hybridization (ISH).

Spec (determined) Gene_expression (Expression) of IL-2Rgamma

1) Confidence 0.75 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10778976 Disease Relevance 0.88 Pain Relevance 0.10

In the pathological sections, expression of IL-2Ralpha, IL-2Rbeta, and IL-2Rgamma was detected in 17 (18.1%), 83 (89.2%), and 83 (89.2%) cases, respectively, by IHC, and the message of IL-2Ralpha was identified in tumor cells by ISH in 30.1% (28 of 93) of the cases.

Gene_expression (expression) of IL-2Rgamma associated with cancer

2) Confidence 0.75 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10778976 Disease Relevance 0.93 Pain Relevance 0.06

In the pathological sections, expression of IL-2Ralpha, IL-2Rbeta, and IL-2Rgamma was detected in 17 (18.1%), 83 (89.2%), and 83 (89.2%) cases, respectively, by IHC, and the message of IL-2Ralpha was identified in tumor cells by ISH in 30.1% (28 of 93) of the cases.

Gene_expression (detected) of IL-2Rgamma associated with cancer

3) Confidence 0.58 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10778976 Disease Relevance 0.92 Pain Relevance 0.06

We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha, and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.

Gene_expression (synthesis) of soluble interleukin-2 receptor associated with necrosis, anesthesia and cancer

4) Confidence 0.43 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143381 Disease Relevance 0.36 Pain Relevance 0.52

Increases in blood natural killer cell activity and levels of IFN-gamma, interleukin-10, and activation markers (soluble interleukin-2 receptor and soluble intercellular adhesion molecule-1) were often seen.

Gene_expression (levels) of interleukin-2 receptor in natural killer cell associated with adhesions

5) Confidence 0.41 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10815893 Disease Relevance 1.22 Pain Relevance 0.10

There was no obvious correlation with the expression of CD122 or CD132.25

Gene_expression (expression) of CD132

6) Confidence 0.41 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 1.50 Pain Relevance 0

Serum levels of IL-2R correlated strongly with clinical and laboratory indicators of disease activity in patients with lupus and in those with rheumatoid arthritis.

Gene_expression (levels) of IL-2R associated with rheumatoid arthritis, systemic lupus erythematosus and disease

7) Confidence 0.36 Published 1988 Journal Arthritis Rheum. Section Abstract Doc Link 3263865 Disease Relevance 0.83 Pain Relevance 0.13

Our findings indicate that serum levels of IL-2R may serve as a reliable serologic indicator of disease activity in inflammatory diseases characterized by immune system activation.

Gene_expression (levels) of IL-2R in immune system associated with inflammation and disease

8) Confidence 0.36 Published 1988 Journal Arthritis Rheum. Section Abstract Doc Link 3263865 Disease Relevance 1.06 Pain Relevance 0.13

Levels of interleukin-2 receptors (IL-2R), as measured by a double-antibody "sandwich" enzyme-linked immunosorbent assay technique, were markedly elevated in the serum of patients with systemic lupus erythematosus, rheumatoid arthritis, and bacterial endocarditis, but not in patients with acute gout.

Gene_expression (Levels) of IL-2R associated with bacterial endocarditis, rheumatoid arthritis, crystal associated disease and systemic lupus erythematosus

9) Confidence 0.36 Published 1988 Journal Arthritis Rheum. Section Abstract Doc Link 3263865 Disease Relevance 0.71 Pain Relevance 0.08

Lymphocyte counts increased in all patients affecting both T-helper and T-suppressor cells; however, the lymphocytes were not activated as analyzed by the expression of the interleukin-2 receptor.

Spec (analyzed) Gene_expression (expression) of interleukin-2 receptor in Lymphocyte

10) Confidence 0.34 Published 1989 Journal Blood Section Abstract Doc Link 2642714 Disease Relevance 0.62 Pain Relevance 0.07

We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, INF-alpha, tumor necrosis factor (TNF)-alpha and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.

Gene_expression (synthesis) of interleukin-2 receptor

11) Confidence 0.29 Published 1998 Journal Anaesthesist Section Body Doc Link 9645277 Disease Relevance 0.07 Pain Relevance 0

This agent is an interleukin-2 receptor (IL-2R)-targeted cytotoxin which kills activated IL-2R-expressing lymphocytes at 10(-10) M concentrations.

Gene_expression (expressing) of IL-2R in lymphocytes

12) Confidence 0.11 Published 1993 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 8324945 Disease Relevance 0.37 Pain Relevance 0.14

DAB(389)IL-2 (denileukin diftitox, ONTAK) is a cytokine-targeted fusion protein that delivers the catalytic domain of diphtheria toxin to lymphoma cells expressing the interleukin-2 receptor (IL-2R).

Gene_expression (expressing) of interleukin-2 receptor associated with lymphatic system cancer, diphtheria and cytokine

13) Confidence 0.07 Published 2001 Journal Clin Lymphoma Section Abstract Doc Link 11707845 Disease Relevance 1.06 Pain Relevance 0.13

DAB(389)IL-2 (denileukin diftitox, ONTAK) is a cytokine-targeted fusion protein that delivers the catalytic domain of diphtheria toxin to lymphoma cells expressing the interleukin-2 receptor (IL-2R).

Gene_expression (expressing) of IL-2R associated with lymphatic system cancer, diphtheria and cytokine

14) Confidence 0.07 Published 2001 Journal Clin Lymphoma Section Abstract Doc Link 11707845 Disease Relevance 1.06 Pain Relevance 0.13

By comparison, there was no significant difference in mean serum levels of IL-2R in individuals with Crohn's disease compared with these other groups.

Gene_expression (levels) of IL-2R associated with crohn's disease and disease

15) Confidence 0.06 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 8856584 Disease Relevance 1.84 Pain Relevance 0.61

Patients with moderate/severe Crohn's disease had elevated mean serum levels of IL-6 and IL-2R when compared with those with mild and inactive disease (p < 0.05); however, neither marker distinguished between inactive and mild disease.

Gene_expression (levels) of IL-2R associated with crohn's disease and disease

16) Confidence 0.06 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 8856584 Disease Relevance 1.78 Pain Relevance 0.59

Serum levels of IL-6 and IL-2R were determined by using an enzyme-linked immunosorbent assay.

Gene_expression (levels) of IL-2R

17) Confidence 0.06 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 8856584 Disease Relevance 1.76 Pain Relevance 0.54

Previous studies have demonstrated elevated serum levels of interleukin-6 (IL-6) and the soluble interleukin-2 receptor (IL-2R, CD25) in individuals with inflammatory bowel disease (IBD).

Gene_expression (levels) of IL-2R in bowel associated with inflammatory bowel disease and inflammation

18) Confidence 0.06 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 8856584 Disease Relevance 1.05 Pain Relevance 0.26

Previous studies have demonstrated elevated serum levels of interleukin-6 (IL-6) and the soluble interleukin-2 receptor (IL-2R, CD25) in individuals with inflammatory bowel disease (IBD).

Gene_expression (levels) of interleukin-2 receptor in bowel associated with inflammatory bowel disease and inflammation

19) Confidence 0.06 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 8856584 Disease Relevance 1.05 Pain Relevance 0.25

However, no influence of immunosuppressive factors such as alcohol consumption, cigarette smoking, or diabetes could be detected on the levels of IL-2r, CD44, CD44v6, and neopterin.

Gene_expression (levels) of IL-2r

20) Confidence 0.04 Published 2001 Journal Pancreas Section Body Doc Link 11668200 Disease Relevance 0.06 Pain Relevance 0

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