INT276282

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.41
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Atrn, Mc1r) plasma membrane (Atrn, Mc1r) signal transduction (Mc1r)
extracellular space (Atrn) signal transducer activity (Mc1r) cytoplasm (Atrn)
Anatomy Link Frequency
melanocytes 1
Atrn (Mus musculus)
Mc1r (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 80 100.00 Very High Very High Very High
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Freckles 102 86.88 High High
Targeted Disruption 2 38.48 Quite Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protein products of three of these genes, Mc1r, Agouti, and Atrn, interact at the surface of pigment-producing cells (melanocytes) and constitute the machinery responsible for “pigment type switching,” the ability of melanocytes to switch between the production of dark brown/black (eumelanin) and light yellow/red pigment (pheomelanin).
Atrn Binding (interact) of Mc1r in melanocytes associated with melanocortin 1 receptor
1) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.16 Pain Relevance 0.49
The functions of Atrn and Mgrn are not as well understood, although Atrn is thought to stabilize interactions between Mc1r and Agouti [11].
Atrn Binding (interactions) of Mc1r associated with melanocortin 1 receptor
2) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.26 Pain Relevance 0.80

General Comments

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