INT276307

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) endosome (Cdkn1b) cell death (Cdkn1b)
nucleus (Cdkn1b) cell cycle (Cdkn1b) protein complex (Cdkn1b)
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 11 97.66 Very High Very High Very High
Mantle-cell Lymphoma 33 89.24 High High
Cancer 227 87.12 High High
Apoptosis 69 82.76 Quite High
Targeted Disruption 2 70.96 Quite High
Toxicity 6 59.68 Quite High
Syndrome 8 57.36 Quite High
Lymphatic System Cancer 124 50.00 Quite Low
Severe Combined Immunodeficiency 2 20.72 Low Low
Diffuse Large B-cell Lymphoma 56 9.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Maddika et al indicated that inhibitors of PI3-kinase or Akt not only inhibited CDK2 activation but also protected cells from Apoptin-induced cell death, and Akt-mediated activation of CDK2 was caused by direct phosphorylation as well as by the phosphorylation-induced degradation of its inhibitor p27 (Kip1) [32].
Protein_catabolism (degradation) of Kip1 associated with death
1) Confidence 0.45 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.00 Pain Relevance 0
Maddika et al indicated that inhibitors of PI3-kinase or Akt not only inhibited CDK2 activation but also protected cells from Apoptin-induced cell death, and Akt-mediated activation of CDK2 was caused by direct phosphorylation as well as by the phosphorylation-induced degradation of its inhibitor p27 (Kip1) [32].
Protein_catabolism (degradation) of p27 associated with death
2) Confidence 0.45 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.00 Pain Relevance 0
These effects are mediated by nuclear accumulation of the p27(Kip1) inhibitor induced by the downregulation of the p45(Skp2) and Cks1 proteins, which target p27(Kip1) for degradation.
Protein_catabolism (degradation) of p27
3) Confidence 0.09 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.57 Pain Relevance 0

General Comments

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