INT276309

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.97
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prdm1) intracellular (Prdm1) DNA binding (Prdm1)
cytoplasm (Prdm1)
Anatomy Link Frequency
B cell 1
Prdm1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 74.04 Quite High
chemokine 10 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hodgkin's Disease 50 97.88 Very High Very High Very High
Diffuse Large B-cell Lymphoma 112 89.68 High High
B-cell Lymphoma 54 89.40 High High
Cancer 82 86.20 High High
Lymphatic System Cancer 244 59.68 Quite High
Sclerosis 2 47.88 Quite Low
Mantle-cell Lymphoma 66 5.00 Very Low Very Low Very Low
Epstein-barr Virus 60 5.00 Very Low Very Low Very Low
Follicular Lymphoma 44 5.00 Very Low Very Low Very Low
Disease 44 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MiRNA-mediated downregulation of PRDM1/Blimp-1 may contribute to the phenotype maintenance and pathogenesis of HRS cells by interfering with normal B cell terminal differentiation, thus representing a novel molecular lesion, as well as a potential therapeutic target in HL [2].
Negative_regulation (downregulation) of PRDM1 in B cell associated with hodgkin's disease
1) Confidence 0.18 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.00 Pain Relevance 0.06
untranslated region of PRDM1/Blimp-1 mRNA and high levels of miR-9 and let-7a in HL cell lines correlated with low levels of PRDM1/Blimp-1.
Negative_regulation (region) of PRDM1 associated with hodgkin's disease
2) Confidence 0.13 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.97 Pain Relevance 0.07

General Comments

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