INT276310

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 4.18
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cell 4
Pdcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 30 99.36 Very High Very High Very High
cytokine 39 86.80 High High
chemokine 10 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diffuse Cutaneous Leishmaniasis 370 100.00 Very High Very High Very High
Lymphatic System Cancer 244 99.36 Very High Very High Very High
Hyperplasia 11 95.68 Very High Very High Very High
Infection 106 94.32 High High
Death 37 93.12 High High
B-cell Lymphoma 54 92.96 High High
Hodgkin's Disease 50 91.12 High High
Disease 104 83.20 Quite High
Apoptosis 95 73.92 Quite High
Chronic Lymphoid Leukemia 8 70.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
production were restored with both stimuli, whereas PD-1 (a molecule associated with cellular exhaustion) expression, was reduced.
Negative_regulation (reduced) of Gene_expression (expression) of PD-1
1) Confidence 0.05 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2970528 Disease Relevance 0.56 Pain Relevance 0.05
Recently, Wong and co-workers [18] demonstrated that peptide vaccination in the presence of CpG ODN (TLR9 ligand) reduced expression of PD-1 in mice.
Negative_regulation (reduced) of Gene_expression (expression) of PD-1
2) Confidence 0.05 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.38 Pain Relevance 0
We found that PD-1 expression in CD8+ of DCL patients was significantly reduced after stimulation with both TLR2 agonists, LPG (p?
Negative_regulation (reduced) of Gene_expression (expression) of PD-1 associated with agonist and diffuse cutaneous leishmaniasis
3) Confidence 0.05 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.63 Pain Relevance 0.14
In addition to restoring these functions, TLR2-stimulated CD8 cells showed a reduction in PD-1 expression, a molecule frequently present in cellular exhaustion.
Negative_regulation (reduction) of Gene_expression (expression) of PD-1
4) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.80 Pain Relevance 0.13
Therefore, we hypothesized that TLR2 stimulation could reduce PD-1 expression and restore CD8 functional activity in DCL patients against MOi.
Negative_regulation (reduce) of Gene_expression (expression) of PD-1 associated with diffuse cutaneous leishmaniasis
5) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.30 Pain Relevance 0
PD-1 expression was also reported in some T cell NHL subtypes.
Negative_regulation (reported) of Gene_expression (expression) of PD-1 in T cell associated with lymphatic system cancer
6) Confidence 0.02 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.85 Pain Relevance 0
The presence of PD-1-positive T cell rosettes, therefore, seems to be an additional useful feature in the sometimes difficult differential diagnosis of NLPHL and T/HRBCL; in borderline cases (probably discussed in Bordeaux!)
Negative_regulation (feature) of Gene_expression (presence) of PD-1 in T cell
7) Confidence 0.02 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.66 Pain Relevance 0

General Comments

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